Influence of Molecular Design on the Tumor Targeting and Biodistribution of PSMA-Binding Tracers Labeled with Technetium-99m

Influence of Molecular Design on the Tumor Targeting and Biodistribution of PSMA-Binding Tracers Labeled with Technetium-99m

Previously, we designed the EuK-based PSMA ligand BQ0413 with an maE<sub>3</sub> chelator for labeling with technetium-99m. It showed efficient tumor targeting, but our preclinical data and preliminary clinical results indicated that the renal excretion levels need to be decreased. We hy...

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Bibliographic Details
Main Authors: Ekaterina Bezverkhniaia, Panagiotis Kanellopoulos, Ulrika Rosenström, Vladimir Tolmachev, Anna Orlova
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:International Journal of Molecular Sciences
Subjects:
prostate cancer
prostate-specific membrane antigen
PSMA
technetium-99m
coupling linker
BQ0411
Online Access:https://www.mdpi.com/1422-0067/25/7/3615

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