Determination of parecoxib and valdecoxib in rat plasma by UPLC-MS/MS and its application to pharmacokinetics studies

Determination of parecoxib and valdecoxib in rat plasma by UPLC-MS/MS and its application to pharmacokinetics studies

Abstract Background The present study aimed to develop and validate a rapid, selective, and reproducible ultra-performance liquid chromatography-tandem mass spectrometry separation method for the simultaneous determination of the levels of parecoxib and its main metabolite valdecoxib in rat plasma....

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Bibliographic Details
Main Authors: Mengchun Chen, Wei Sun, Zhe Wang, Chengke Huang, Guoxin Hu, Yijie Chen, Ledan Wang
Format: Article
Language:English
Published: BMC 2020-04-01
Series:BMC Pharmacology and Toxicology
Subjects:
Parecoxib
Valdecoxib
UPLC–MS/MS
Rat plasma
Pharmacokinetics
Online Access:http://link.springer.com/article/10.1186/s40360-020-00406-5

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