Characterization of a candidate tetravalent vaccine based on 2'-O-methyltransferase mutants.

Characterization of a candidate tetravalent vaccine based on 2'-O-methyltransferase mutants.

Dengue virus (DENV) is one of the most widespread arboviruses. The four DENV serotypes infect about 400 million people every year, causing 96 million clinical dengue cases, of which approximately 500'000 are severe and potentially life-threatening. The only licensed vaccine has a limited effica...

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Main Authors: Roland Züst, Shi-Hua Li, Xuping Xie, Sumathy Velumani, Melissa Chng, Ying-Xiu Toh, Jing Zou, Hongping Dong, Chao Shan, Jassia Pang, Cheng-Feng Qin, Evan W Newell, Pei-Yong Shi, Katja Fink
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5751980?pdf=render

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