Porcine SLITRK1: Molecular cloning and characterization
The membrane protein SLITRK1 functions as a developmentally regulated stimulator of neurite outgrowth and variants in this gene have been implicated in Tourette syndrome. In the current study we have cloned and characterized the porcine SLITRK1 gene. The genomic organization of SLITRK1 lacks introns...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | FEBS Open Bio |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211546314000904 |
| _version_ | 1828519705358368768 |
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| author | Knud Larsen Jamal Momeni Leila Farajzadeh Christian Bendixen |
| author_facet | Knud Larsen Jamal Momeni Leila Farajzadeh Christian Bendixen |
| author_sort | Knud Larsen |
| collection | DOAJ |
| description | The membrane protein SLITRK1 functions as a developmentally regulated stimulator of neurite outgrowth and variants in this gene have been implicated in Tourette syndrome. In the current study we have cloned and characterized the porcine SLITRK1 gene. The genomic organization of SLITRK1 lacks introns, as does its human and mouse counterparts. RT-PCR cloning revealed two SLITRK1 transcripts: a full-length mRNA and a transcript variant that results in a truncated protein. The encoded SLITRK1 protein, consisting of 695 amino acids, displays a very high homology to human SLITRK1 (99%). The porcine SLITRK1 gene is expressed exclusively in brain tissues. |
| first_indexed | 2024-12-11T19:16:34Z |
| format | Article |
| id | doaj.art-5661dfd5d4704bcebef1b52891f66072 |
| institution | Directory Open Access Journal |
| issn | 2211-5463 |
| language | English |
| last_indexed | 2024-12-11T19:16:34Z |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | FEBS Open Bio |
| spelling | doaj.art-5661dfd5d4704bcebef1b52891f660722022-12-22T00:53:38ZengWileyFEBS Open Bio2211-54632014-01-014C87287810.1016/j.fob.2014.10.001Porcine SLITRK1: Molecular cloning and characterizationKnud LarsenJamal MomeniLeila FarajzadehChristian BendixenThe membrane protein SLITRK1 functions as a developmentally regulated stimulator of neurite outgrowth and variants in this gene have been implicated in Tourette syndrome. In the current study we have cloned and characterized the porcine SLITRK1 gene. The genomic organization of SLITRK1 lacks introns, as does its human and mouse counterparts. RT-PCR cloning revealed two SLITRK1 transcripts: a full-length mRNA and a transcript variant that results in a truncated protein. The encoded SLITRK1 protein, consisting of 695 amino acids, displays a very high homology to human SLITRK1 (99%). The porcine SLITRK1 gene is expressed exclusively in brain tissues.http://www.sciencedirect.com/science/article/pii/S2211546314000904DNA methylationPigSLITRK1Tourette |
| spellingShingle | Knud Larsen Jamal Momeni Leila Farajzadeh Christian Bendixen Porcine SLITRK1: Molecular cloning and characterization FEBS Open Bio DNA methylation Pig SLITRK1 Tourette |
| title | Porcine SLITRK1: Molecular cloning and characterization |
| title_full | Porcine SLITRK1: Molecular cloning and characterization |
| title_fullStr | Porcine SLITRK1: Molecular cloning and characterization |
| title_full_unstemmed | Porcine SLITRK1: Molecular cloning and characterization |
| title_short | Porcine SLITRK1: Molecular cloning and characterization |
| title_sort | porcine slitrk1 molecular cloning and characterization |
| topic | DNA methylation Pig SLITRK1 Tourette |
| url | http://www.sciencedirect.com/science/article/pii/S2211546314000904 |
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