Does FVL have an effect on longevity?
Background: Different genetic and non-genetic factors have been reported to play a role in human longevity. Longevity has been associated with genetically favourable conditions which protected humans from cardiovascular disease (CVD). We have tried to confirm this statement in Turkish young and old...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2014-07-01
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| Series: | Egyptian Journal of Medical Human Genetics |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1110863014000330 |
| _version_ | 1818281189218189312 |
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| author | Dilara Fatma Akın Yonca Eğin Nejat Akar |
| author_facet | Dilara Fatma Akın Yonca Eğin Nejat Akar |
| author_sort | Dilara Fatma Akın |
| collection | DOAJ |
| description | Background: Different genetic and non-genetic factors have been reported to play a role in human longevity. Longevity has been associated with genetically favourable conditions which protected humans from cardiovascular disease (CVD). We have tried to confirm this statement in Turkish young and old aged groups.
Aim of the study: We aimed to investigate selected genetic polymorphisms (Factor V 1691 G-A, Prothrombin 20210 G-A and methylenetetrahydrofolate reductase 677 C-T) in CVD and controls to analyse their effects on longevity.
Patients and methods: The case control study included 362 persons aged 0–18 years and 209 persons aged 70 and above with diagnosis of thrombosis. Genetic polymorphisms were detected with Light Cycler Real Time PCR.
Results: The results were compared to those of 332 and 266 healthy persons of same age groups who served as controls. MTHFR 677 C-T and PT 20210 G-A genotype frequencies in the old and young study groups were similar for all polymorphisms, but MTHFR 677T may have synergy with FVL (Factor V Leiden) imparting a risk of thromboembolism.
Conclusion: This study concludes that common variations in genes associated with cardiovascular risk do not contribute significantly to longevity. |
| first_indexed | 2024-12-13T00:01:10Z |
| format | Article |
| id | doaj.art-56634949febd464092eda20941a57f12 |
| institution | Directory Open Access Journal |
| issn | 1110-8630 |
| language | English |
| last_indexed | 2024-12-13T00:01:10Z |
| publishDate | 2014-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Journal of Medical Human Genetics |
| spelling | doaj.art-56634949febd464092eda20941a57f122022-12-22T00:06:25ZengSpringerOpenEgyptian Journal of Medical Human Genetics1110-86302014-07-0115328128510.1016/j.ejmhg.2014.02.009Does FVL have an effect on longevity?Dilara Fatma Akın0Yonca Eğin1Nejat Akar2LOSEV Foundation for Children with Leukemia, Ankara, TurkeyDepartment of Pediatric Genetics, Ankara University, Ankara, TurkeyTOBB-ETU Hospital, Ankara, TurkeyBackground: Different genetic and non-genetic factors have been reported to play a role in human longevity. Longevity has been associated with genetically favourable conditions which protected humans from cardiovascular disease (CVD). We have tried to confirm this statement in Turkish young and old aged groups. Aim of the study: We aimed to investigate selected genetic polymorphisms (Factor V 1691 G-A, Prothrombin 20210 G-A and methylenetetrahydrofolate reductase 677 C-T) in CVD and controls to analyse their effects on longevity. Patients and methods: The case control study included 362 persons aged 0–18 years and 209 persons aged 70 and above with diagnosis of thrombosis. Genetic polymorphisms were detected with Light Cycler Real Time PCR. Results: The results were compared to those of 332 and 266 healthy persons of same age groups who served as controls. MTHFR 677 C-T and PT 20210 G-A genotype frequencies in the old and young study groups were similar for all polymorphisms, but MTHFR 677T may have synergy with FVL (Factor V Leiden) imparting a risk of thromboembolism. Conclusion: This study concludes that common variations in genes associated with cardiovascular risk do not contribute significantly to longevity.http://www.sciencedirect.com/science/article/pii/S1110863014000330ThrombosisFactor VProthrombin 20210 G-AMTHFR 677 C-T |
| spellingShingle | Dilara Fatma Akın Yonca Eğin Nejat Akar Does FVL have an effect on longevity? Egyptian Journal of Medical Human Genetics Thrombosis Factor V Prothrombin 20210 G-A MTHFR 677 C-T |
| title | Does FVL have an effect on longevity? |
| title_full | Does FVL have an effect on longevity? |
| title_fullStr | Does FVL have an effect on longevity? |
| title_full_unstemmed | Does FVL have an effect on longevity? |
| title_short | Does FVL have an effect on longevity? |
| title_sort | does fvl have an effect on longevity |
| topic | Thrombosis Factor V Prothrombin 20210 G-A MTHFR 677 C-T |
| url | http://www.sciencedirect.com/science/article/pii/S1110863014000330 |
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