Microfluidization trends in the development of nanodelivery systems and applications in chronic disease treatments
Palanivel Ganesan,1 Govindarajan Karthivashan,2 Shin Young Park,2 Joonsoo Kim,2 Dong-Kug Choi1,2 1Department of Integrated Bio Science and Biotechnology, College of Biomedical and Health Science, Nanotechnology Research Center, Konkuk University, Chungju 27478, Republic of Korea; 2Department of App...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2018-10-01
|
| Series: | International Journal of Nanomedicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/microfluidization-trends-in-the-development-of-nanodelivery-systems-an-peer-reviewed-article-IJN |
| _version_ | 1818683625335422976 |
|---|---|
| author | Ganesan P Karthivashan G Park S Kim J Choi DK |
| author_facet | Ganesan P Karthivashan G Park S Kim J Choi DK |
| author_sort | Ganesan P |
| collection | DOAJ |
| description | Palanivel Ganesan,1 Govindarajan Karthivashan,2 Shin Young Park,2 Joonsoo Kim,2 Dong-Kug Choi1,2 1Department of Integrated Bio Science and Biotechnology, College of Biomedical and Health Science, Nanotechnology Research Center, Konkuk University, Chungju 27478, Republic of Korea; 2Department of Applied Life Sciences, Graduate School of Konkuk University, Research Institute of Inflammatory Diseases, Chungju 27478, Republic of Korea Abstract: Plant bioactive compounds are known for their extensive health benefits and therefore have been used for generations in traditional and modern medicine to improve the health of humans. Processing and storage instabilities of the plant bioactive compounds, however, limit their bioavailability and bioaccessibility and thus lead researchers in search of novel encapsulation systems with enhanced stability, bioavailability, and bioaccessibility of encapsulated plant bioactive compounds. Recently many varieties of encapsulation methods have been used; among them, microfluidization has emerged as a novel method used for the development of delivery systems including solid lipid nanocarriers, nanoemulsions, liposomes, and so on with enhanced stability and bioavailability of encapsulated plant bioactive compounds. Therefore, the nanodelivery systems developed using microfluidization techniques have received much attention from the medical industry for their ability to facilitate controlled delivery with enhanced health benefits in the treatment of various chronic diseases. Many researchers have focused on plant bioactive compound-based delivery systems using microfluidization to enhance the bioavailability and bioaccessibility of encapsulated bioactive compounds in the treatment of various chronic diseases. This review focuses on various nanodelivery systems developed using microfluidization techniques and applications in various chronic disease treatments. Keywords: bioavailability, solid lipid nanoparticles, plant bioactive compounds, nanoemulsions |
| first_indexed | 2024-12-17T10:37:43Z |
| format | Article |
| id | doaj.art-566373cccc81454fb1b04f6810d5beca |
| institution | Directory Open Access Journal |
| issn | 1178-2013 |
| language | English |
| last_indexed | 2024-12-17T10:37:43Z |
| publishDate | 2018-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-566373cccc81454fb1b04f6810d5beca2022-12-21T21:52:19ZengDove Medical PressInternational Journal of Nanomedicine1178-20132018-10-01Volume 136109612141226Microfluidization trends in the development of nanodelivery systems and applications in chronic disease treatmentsGanesan PKarthivashan GPark SKim JChoi DKPalanivel Ganesan,1 Govindarajan Karthivashan,2 Shin Young Park,2 Joonsoo Kim,2 Dong-Kug Choi1,2 1Department of Integrated Bio Science and Biotechnology, College of Biomedical and Health Science, Nanotechnology Research Center, Konkuk University, Chungju 27478, Republic of Korea; 2Department of Applied Life Sciences, Graduate School of Konkuk University, Research Institute of Inflammatory Diseases, Chungju 27478, Republic of Korea Abstract: Plant bioactive compounds are known for their extensive health benefits and therefore have been used for generations in traditional and modern medicine to improve the health of humans. Processing and storage instabilities of the plant bioactive compounds, however, limit their bioavailability and bioaccessibility and thus lead researchers in search of novel encapsulation systems with enhanced stability, bioavailability, and bioaccessibility of encapsulated plant bioactive compounds. Recently many varieties of encapsulation methods have been used; among them, microfluidization has emerged as a novel method used for the development of delivery systems including solid lipid nanocarriers, nanoemulsions, liposomes, and so on with enhanced stability and bioavailability of encapsulated plant bioactive compounds. Therefore, the nanodelivery systems developed using microfluidization techniques have received much attention from the medical industry for their ability to facilitate controlled delivery with enhanced health benefits in the treatment of various chronic diseases. Many researchers have focused on plant bioactive compound-based delivery systems using microfluidization to enhance the bioavailability and bioaccessibility of encapsulated bioactive compounds in the treatment of various chronic diseases. This review focuses on various nanodelivery systems developed using microfluidization techniques and applications in various chronic disease treatments. Keywords: bioavailability, solid lipid nanoparticles, plant bioactive compounds, nanoemulsionshttps://www.dovepress.com/microfluidization-trends-in-the-development-of-nanodelivery-systems-an-peer-reviewed-article-IJNmicrofluidizationnanodelivery systemsbioactive compoundschronic diseases |
| spellingShingle | Ganesan P Karthivashan G Park S Kim J Choi DK Microfluidization trends in the development of nanodelivery systems and applications in chronic disease treatments International Journal of Nanomedicine microfluidization nanodelivery systems bioactive compounds chronic diseases |
| title | Microfluidization trends in the development of nanodelivery systems and applications in chronic disease treatments |
| title_full | Microfluidization trends in the development of nanodelivery systems and applications in chronic disease treatments |
| title_fullStr | Microfluidization trends in the development of nanodelivery systems and applications in chronic disease treatments |
| title_full_unstemmed | Microfluidization trends in the development of nanodelivery systems and applications in chronic disease treatments |
| title_short | Microfluidization trends in the development of nanodelivery systems and applications in chronic disease treatments |
| title_sort | microfluidization trends in the development of nanodelivery systems and applications in chronic disease treatments |
| topic | microfluidization nanodelivery systems bioactive compounds chronic diseases |
| url | https://www.dovepress.com/microfluidization-trends-in-the-development-of-nanodelivery-systems-an-peer-reviewed-article-IJN |
| work_keys_str_mv | AT ganesanp microfluidizationtrendsinthedevelopmentofnanodeliverysystemsandapplicationsinchronicdiseasetreatments AT karthivashang microfluidizationtrendsinthedevelopmentofnanodeliverysystemsandapplicationsinchronicdiseasetreatments AT parks microfluidizationtrendsinthedevelopmentofnanodeliverysystemsandapplicationsinchronicdiseasetreatments AT kimj microfluidizationtrendsinthedevelopmentofnanodeliverysystemsandapplicationsinchronicdiseasetreatments AT choidk microfluidizationtrendsinthedevelopmentofnanodeliverysystemsandapplicationsinchronicdiseasetreatments |