3D Printing of Paracetamol Suppositories: An Automated Manufacturing Technique for Individualized Therapy
Pharmaceutical compounding using the molding technique is the currently applied method for the on-demand manufacturing of suppositories and pessaries. Potential errors of this method are difficult to detect, and the possibilities of individualization of size and shape of the suppositories are limite...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/12/2676 |
| _version_ | 1797455715044950016 |
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| author | Vanessa Domsta Julius Krause Werner Weitschies Anne Seidlitz |
| author_facet | Vanessa Domsta Julius Krause Werner Weitschies Anne Seidlitz |
| author_sort | Vanessa Domsta |
| collection | DOAJ |
| description | Pharmaceutical compounding using the molding technique is the currently applied method for the on-demand manufacturing of suppositories and pessaries. Potential errors of this method are difficult to detect, and the possibilities of individualization of size and shape of the suppositories are limited. In this study, a syringe-based semi-solid 3D printing technique was developed for the manufacturing of suppositories in three different printing designs with the suppository bases polyethylene glycol (PEG) and hard fat (HF). The 3D printed suppositories were analyzed for their visual appearance, uniformity of mass and content, diametrical dimension, breaking force and release behavior and compared to suppositories of the same composition prepared by a commonly used molding technique. The results showed no adverse properties for the 3D printed suppositories compared to the molded ones. Moreover, the easy adaptation of shape using the 3D printing technique was demonstrated by the printing of different sizes and infill structures. Thus, 3D printing has great potential to complement the available manufacturing methods for compounded suppositories, as it represents an automated system for the individualized manufacturing of suppositories that meet patients’ needs. |
| first_indexed | 2024-03-09T15:58:18Z |
| format | Article |
| id | doaj.art-56652d5610d844218a0e4fe9fde0db9d |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T15:58:18Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-56652d5610d844218a0e4fe9fde0db9d2023-11-24T17:20:04ZengMDPI AGPharmaceutics1999-49232022-12-011412267610.3390/pharmaceutics141226763D Printing of Paracetamol Suppositories: An Automated Manufacturing Technique for Individualized TherapyVanessa Domsta0Julius Krause1Werner Weitschies2Anne Seidlitz3Institute of Pharmacy, Biopharmaceutics and Pharmaceutical Technology, University of Greifswald, Felix-Hausdorff-Str. 3, 17489 Greifswald, GermanyInstitute of Pharmacy, Biopharmaceutics and Pharmaceutical Technology, University of Greifswald, Felix-Hausdorff-Str. 3, 17489 Greifswald, GermanyInstitute of Pharmacy, Biopharmaceutics and Pharmaceutical Technology, University of Greifswald, Felix-Hausdorff-Str. 3, 17489 Greifswald, GermanyInstitute of Pharmacy, Biopharmaceutics and Pharmaceutical Technology, University of Greifswald, Felix-Hausdorff-Str. 3, 17489 Greifswald, GermanyPharmaceutical compounding using the molding technique is the currently applied method for the on-demand manufacturing of suppositories and pessaries. Potential errors of this method are difficult to detect, and the possibilities of individualization of size and shape of the suppositories are limited. In this study, a syringe-based semi-solid 3D printing technique was developed for the manufacturing of suppositories in three different printing designs with the suppository bases polyethylene glycol (PEG) and hard fat (HF). The 3D printed suppositories were analyzed for their visual appearance, uniformity of mass and content, diametrical dimension, breaking force and release behavior and compared to suppositories of the same composition prepared by a commonly used molding technique. The results showed no adverse properties for the 3D printed suppositories compared to the molded ones. Moreover, the easy adaptation of shape using the 3D printing technique was demonstrated by the printing of different sizes and infill structures. Thus, 3D printing has great potential to complement the available manufacturing methods for compounded suppositories, as it represents an automated system for the individualized manufacturing of suppositories that meet patients’ needs.https://www.mdpi.com/1999-4923/14/12/26763D printingadditive manufacturingsuppositoriespharmaceutical compoundingindividualization |
| spellingShingle | Vanessa Domsta Julius Krause Werner Weitschies Anne Seidlitz 3D Printing of Paracetamol Suppositories: An Automated Manufacturing Technique for Individualized Therapy Pharmaceutics 3D printing additive manufacturing suppositories pharmaceutical compounding individualization |
| title | 3D Printing of Paracetamol Suppositories: An Automated Manufacturing Technique for Individualized Therapy |
| title_full | 3D Printing of Paracetamol Suppositories: An Automated Manufacturing Technique for Individualized Therapy |
| title_fullStr | 3D Printing of Paracetamol Suppositories: An Automated Manufacturing Technique for Individualized Therapy |
| title_full_unstemmed | 3D Printing of Paracetamol Suppositories: An Automated Manufacturing Technique for Individualized Therapy |
| title_short | 3D Printing of Paracetamol Suppositories: An Automated Manufacturing Technique for Individualized Therapy |
| title_sort | 3d printing of paracetamol suppositories an automated manufacturing technique for individualized therapy |
| topic | 3D printing additive manufacturing suppositories pharmaceutical compounding individualization |
| url | https://www.mdpi.com/1999-4923/14/12/2676 |
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