Distinct genetic loci control plasma HIV-RNA and cellular HIV-DNA levels in HIV-1 infection: the ANRS Genome Wide Association 01 study.
Previous studies of the HIV-1 disease have shown that HLA and Chemokine receptor genetic variants influence disease progression and early viral load. We performed a Genome Wide Association study in a cohort of 605 HIV-1-infected seroconverters for detection of novel genetic factors that influence pl...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2008-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2603319?pdf=render |
| _version_ | 1818174406341427200 |
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| author | Cyril Dalmasso Wassila Carpentier Laurence Meyer Christine Rouzioux Cécile Goujard Marie-Laure Chaix Olivier Lambotte Véronique Avettand-Fenoel Sigrid Le Clerc Laure Denis de Senneville Christiane Deveau Faroudy Boufassa Patrice Debré Jean-François Delfraissy Philippe Broet Ioannis Theodorou ANRS Genome Wide Association 01 |
| author_facet | Cyril Dalmasso Wassila Carpentier Laurence Meyer Christine Rouzioux Cécile Goujard Marie-Laure Chaix Olivier Lambotte Véronique Avettand-Fenoel Sigrid Le Clerc Laure Denis de Senneville Christiane Deveau Faroudy Boufassa Patrice Debré Jean-François Delfraissy Philippe Broet Ioannis Theodorou ANRS Genome Wide Association 01 |
| author_sort | Cyril Dalmasso |
| collection | DOAJ |
| description | Previous studies of the HIV-1 disease have shown that HLA and Chemokine receptor genetic variants influence disease progression and early viral load. We performed a Genome Wide Association study in a cohort of 605 HIV-1-infected seroconverters for detection of novel genetic factors that influence plasma HIV-RNA and cellular HIV-DNA levels. Most of the SNPs strongly associated with HIV-RNA levels were localised in the 6p21 major histocompatibility complex (MHC) region and were in the vicinity of class I and III genes. Moreover, protective alleles for four disease-associated SNPs in the MHC locus (rs2395029, rs13199524, rs12198173 and rs3093662) were strikingly over-represented among forty-five Long Term HIV controllers. Furthermore, we show that the HIV-DNA levels (reflecting the HIV reservoir) are associated with the same four SNPs, but also with two additional SNPs on chromosome 17 (rs6503919; intergenic region flanked by the DDX40 and YPEL2 genes) and chromosome 8 (rs2575735; within the Syndecan 2 gene). Our data provide evidence that the MHC controls both HIV replication and HIV reservoir. They also indicate that two additional genomic loci may influence the HIV reservoir. |
| first_indexed | 2024-12-11T19:43:54Z |
| format | Article |
| id | doaj.art-5665848533ce42dca1259f0f44a6bc6e |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T19:43:54Z |
| publishDate | 2008-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-5665848533ce42dca1259f0f44a6bc6e2022-12-22T00:52:57ZengPublic Library of Science (PLoS)PLoS ONE1932-62032008-01-01312e390710.1371/journal.pone.0003907Distinct genetic loci control plasma HIV-RNA and cellular HIV-DNA levels in HIV-1 infection: the ANRS Genome Wide Association 01 study.Cyril DalmassoWassila CarpentierLaurence MeyerChristine RouziouxCécile GoujardMarie-Laure ChaixOlivier LambotteVéronique Avettand-FenoelSigrid Le ClercLaure Denis de SennevilleChristiane DeveauFaroudy BoufassaPatrice DebréJean-François DelfraissyPhilippe BroetIoannis TheodorouANRS Genome Wide Association 01Previous studies of the HIV-1 disease have shown that HLA and Chemokine receptor genetic variants influence disease progression and early viral load. We performed a Genome Wide Association study in a cohort of 605 HIV-1-infected seroconverters for detection of novel genetic factors that influence plasma HIV-RNA and cellular HIV-DNA levels. Most of the SNPs strongly associated with HIV-RNA levels were localised in the 6p21 major histocompatibility complex (MHC) region and were in the vicinity of class I and III genes. Moreover, protective alleles for four disease-associated SNPs in the MHC locus (rs2395029, rs13199524, rs12198173 and rs3093662) were strikingly over-represented among forty-five Long Term HIV controllers. Furthermore, we show that the HIV-DNA levels (reflecting the HIV reservoir) are associated with the same four SNPs, but also with two additional SNPs on chromosome 17 (rs6503919; intergenic region flanked by the DDX40 and YPEL2 genes) and chromosome 8 (rs2575735; within the Syndecan 2 gene). Our data provide evidence that the MHC controls both HIV replication and HIV reservoir. They also indicate that two additional genomic loci may influence the HIV reservoir.http://europepmc.org/articles/PMC2603319?pdf=render |
| spellingShingle | Cyril Dalmasso Wassila Carpentier Laurence Meyer Christine Rouzioux Cécile Goujard Marie-Laure Chaix Olivier Lambotte Véronique Avettand-Fenoel Sigrid Le Clerc Laure Denis de Senneville Christiane Deveau Faroudy Boufassa Patrice Debré Jean-François Delfraissy Philippe Broet Ioannis Theodorou ANRS Genome Wide Association 01 Distinct genetic loci control plasma HIV-RNA and cellular HIV-DNA levels in HIV-1 infection: the ANRS Genome Wide Association 01 study. PLoS ONE |
| title | Distinct genetic loci control plasma HIV-RNA and cellular HIV-DNA levels in HIV-1 infection: the ANRS Genome Wide Association 01 study. |
| title_full | Distinct genetic loci control plasma HIV-RNA and cellular HIV-DNA levels in HIV-1 infection: the ANRS Genome Wide Association 01 study. |
| title_fullStr | Distinct genetic loci control plasma HIV-RNA and cellular HIV-DNA levels in HIV-1 infection: the ANRS Genome Wide Association 01 study. |
| title_full_unstemmed | Distinct genetic loci control plasma HIV-RNA and cellular HIV-DNA levels in HIV-1 infection: the ANRS Genome Wide Association 01 study. |
| title_short | Distinct genetic loci control plasma HIV-RNA and cellular HIV-DNA levels in HIV-1 infection: the ANRS Genome Wide Association 01 study. |
| title_sort | distinct genetic loci control plasma hiv rna and cellular hiv dna levels in hiv 1 infection the anrs genome wide association 01 study |
| url | http://europepmc.org/articles/PMC2603319?pdf=render |
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