Chemokines and their role in airway hyper-reactivity
<p>Abstract</p> <p>Airway hyper-reactivity is a characteristic feature of many inflammatory lung diseases and is defined as an exaggerated degree of airway narrowing. Chemokines and their receptors are involved in several pathological processes that are believed to contribute to ai...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2000-07-01
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| Series: | Respiratory Research |
| Subjects: | |
| Online Access: | http://respiratory-research.com/content/1/1/054 |
| _version_ | 1818493397440135168 |
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| author | Hogaboam Cory M Lukacs Nicholas W Blease Kate Kunkel Steven L |
| author_facet | Hogaboam Cory M Lukacs Nicholas W Blease Kate Kunkel Steven L |
| author_sort | Hogaboam Cory M |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Airway hyper-reactivity is a characteristic feature of many inflammatory lung diseases and is defined as an exaggerated degree of airway narrowing. Chemokines and their receptors are involved in several pathological processes that are believed to contribute to airway hyper-responsiveness, including recruitment and activation of inflammatory cells, collagen deposition and airway wall remodeling. These proteins are therefore thought to represent important therapeutic targets in the treatment of airway hyper-responsiveness. This review highlights the processes thought to be involved in airway hyper-responsiveness in allergic asthma, and the role of chemokines in these processes. Overall, the application of chemokines to the prevention or treatment of airway hyper-reactivity has tremendous potential.</p> |
| first_indexed | 2024-12-10T17:54:42Z |
| format | Article |
| id | doaj.art-56678d21961f4303b5427c08963c333c |
| institution | Directory Open Access Journal |
| issn | 1465-9921 |
| language | English |
| last_indexed | 2024-12-10T17:54:42Z |
| publishDate | 2000-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-56678d21961f4303b5427c08963c333c2022-12-22T01:38:59ZengBMCRespiratory Research1465-99212000-07-0111546110.1186/rr13Chemokines and their role in airway hyper-reactivityHogaboam Cory MLukacs Nicholas WBlease KateKunkel Steven L<p>Abstract</p> <p>Airway hyper-reactivity is a characteristic feature of many inflammatory lung diseases and is defined as an exaggerated degree of airway narrowing. Chemokines and their receptors are involved in several pathological processes that are believed to contribute to airway hyper-responsiveness, including recruitment and activation of inflammatory cells, collagen deposition and airway wall remodeling. These proteins are therefore thought to represent important therapeutic targets in the treatment of airway hyper-responsiveness. This review highlights the processes thought to be involved in airway hyper-responsiveness in allergic asthma, and the role of chemokines in these processes. Overall, the application of chemokines to the prevention or treatment of airway hyper-reactivity has tremendous potential.</p>http://respiratory-research.com/content/1/1/054asthmaeosinophilsfibrosisT cells |
| spellingShingle | Hogaboam Cory M Lukacs Nicholas W Blease Kate Kunkel Steven L Chemokines and their role in airway hyper-reactivity Respiratory Research asthma eosinophils fibrosis T cells |
| title | Chemokines and their role in airway hyper-reactivity |
| title_full | Chemokines and their role in airway hyper-reactivity |
| title_fullStr | Chemokines and their role in airway hyper-reactivity |
| title_full_unstemmed | Chemokines and their role in airway hyper-reactivity |
| title_short | Chemokines and their role in airway hyper-reactivity |
| title_sort | chemokines and their role in airway hyper reactivity |
| topic | asthma eosinophils fibrosis T cells |
| url | http://respiratory-research.com/content/1/1/054 |
| work_keys_str_mv | AT hogaboamcorym chemokinesandtheirroleinairwayhyperreactivity AT lukacsnicholasw chemokinesandtheirroleinairwayhyperreactivity AT bleasekate chemokinesandtheirroleinairwayhyperreactivity AT kunkelstevenl chemokinesandtheirroleinairwayhyperreactivity |