Experimental Model Systems for Understanding Human Axonal Injury Responses
Neurons are structurally unique and have dendrites and axons that are vulnerable to injury. Some neurons in the peripheral nervous system (PNS) can regenerate their axons after injuries. However, most neurons in the central nervous system (CNS) fail to do so, resulting in irreversible neurological d...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/2/474 |
| _version_ | 1797542247566147584 |
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| author | Bohm Lee Yongcheol Cho |
| author_facet | Bohm Lee Yongcheol Cho |
| author_sort | Bohm Lee |
| collection | DOAJ |
| description | Neurons are structurally unique and have dendrites and axons that are vulnerable to injury. Some neurons in the peripheral nervous system (PNS) can regenerate their axons after injuries. However, most neurons in the central nervous system (CNS) fail to do so, resulting in irreversible neurological disorders. To understand the mechanisms of axon regeneration, various experimental models have been utilized in vivo and in vitro. Here, we collate the key experimental models that revealed the important mechanisms regulating axon regeneration and degeneration in different systems. We also discuss the advantages of experimenting with the rodent model, considering the application of these findings in understanding human diseases and for developing therapeutic methods. |
| first_indexed | 2024-03-10T13:27:57Z |
| format | Article |
| id | doaj.art-566a78992a9c4f26a575b60b997eabc1 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T13:27:57Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-566a78992a9c4f26a575b60b997eabc12023-11-21T08:41:55ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-01-0122247410.3390/ijms22020474Experimental Model Systems for Understanding Human Axonal Injury ResponsesBohm Lee0Yongcheol Cho1Laboratory of Axon Regeneration & Degeneration, Department of Life Sciences, Korea University, Anam-ro 145, Seongbuk-gu, Seoul 02841, KoreaLaboratory of Axon Regeneration & Degeneration, Department of Life Sciences, Korea University, Anam-ro 145, Seongbuk-gu, Seoul 02841, KoreaNeurons are structurally unique and have dendrites and axons that are vulnerable to injury. Some neurons in the peripheral nervous system (PNS) can regenerate their axons after injuries. However, most neurons in the central nervous system (CNS) fail to do so, resulting in irreversible neurological disorders. To understand the mechanisms of axon regeneration, various experimental models have been utilized in vivo and in vitro. Here, we collate the key experimental models that revealed the important mechanisms regulating axon regeneration and degeneration in different systems. We also discuss the advantages of experimenting with the rodent model, considering the application of these findings in understanding human diseases and for developing therapeutic methods.https://www.mdpi.com/1422-0067/22/2/474neurodegenerationaxonal regenerationanimal models |
| spellingShingle | Bohm Lee Yongcheol Cho Experimental Model Systems for Understanding Human Axonal Injury Responses International Journal of Molecular Sciences neurodegeneration axonal regeneration animal models |
| title | Experimental Model Systems for Understanding Human Axonal Injury Responses |
| title_full | Experimental Model Systems for Understanding Human Axonal Injury Responses |
| title_fullStr | Experimental Model Systems for Understanding Human Axonal Injury Responses |
| title_full_unstemmed | Experimental Model Systems for Understanding Human Axonal Injury Responses |
| title_short | Experimental Model Systems for Understanding Human Axonal Injury Responses |
| title_sort | experimental model systems for understanding human axonal injury responses |
| topic | neurodegeneration axonal regeneration animal models |
| url | https://www.mdpi.com/1422-0067/22/2/474 |
| work_keys_str_mv | AT bohmlee experimentalmodelsystemsforunderstandinghumanaxonalinjuryresponses AT yongcheolcho experimentalmodelsystemsforunderstandinghumanaxonalinjuryresponses |