SARS-CoV-2 antibody prevalence among homeless people and shelter workers in Denmark: a nationwide cross-sectional study
Abstract Background People experiencing homelessness (PEH) and associated shelter workers may be at higher risk of infection with “Severe acute respiratory syndrome coronavirus 2” (SARS-CoV-2). The aim of this study was to determine the prevalence of SARS-CoV-2 among PEH and shelter workers in Denma...
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | BMC Public Health |
| Online Access: | https://doi.org/10.1186/s12889-022-13642-7 |
| _version_ | 1828426774949658624 |
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| author | Alexandra R Röthlin Eriksen Kamille Fogh Rasmus B. Hasselbalch Henning Bundgaard Susanne D. Nielsen Charlotte S. Jørgensen Bibi F. S. S. Scharff Christian Erikstrup Susanne G. Sækmose Dorte K. Holm Bitten Aagaard Jonas H. Kristensen Cecilie A. Bødker Jakob B. Norsk Pernille B. Nielsen Lars Østergaard Svend Ellermann-Eriksen Berit Andersen Henrik Nielsen Isik S. Johansen Lothar Wiese Lone Simonsen Thea K.Fischer Fredrik Folke Freddy Lippert Sisse R. Ostrowski Steen Ethelberg Anders Koch Anne-Marie Vangsted Tyra Krause Anders Fomsgaard Claus Nielsen Henrik Ullum Robert Skov Kasper Iversen |
| author_facet | Alexandra R Röthlin Eriksen Kamille Fogh Rasmus B. Hasselbalch Henning Bundgaard Susanne D. Nielsen Charlotte S. Jørgensen Bibi F. S. S. Scharff Christian Erikstrup Susanne G. Sækmose Dorte K. Holm Bitten Aagaard Jonas H. Kristensen Cecilie A. Bødker Jakob B. Norsk Pernille B. Nielsen Lars Østergaard Svend Ellermann-Eriksen Berit Andersen Henrik Nielsen Isik S. Johansen Lothar Wiese Lone Simonsen Thea K.Fischer Fredrik Folke Freddy Lippert Sisse R. Ostrowski Steen Ethelberg Anders Koch Anne-Marie Vangsted Tyra Krause Anders Fomsgaard Claus Nielsen Henrik Ullum Robert Skov Kasper Iversen |
| author_sort | Alexandra R Röthlin Eriksen |
| collection | DOAJ |
| description | Abstract Background People experiencing homelessness (PEH) and associated shelter workers may be at higher risk of infection with “Severe acute respiratory syndrome coronavirus 2” (SARS-CoV-2). The aim of this study was to determine the prevalence of SARS-CoV-2 among PEH and shelter workers in Denmark. Design and methods In November 2020, we conducted a nationwide cross-sectional seroprevalence study among PEH and shelter workers at 21 recruitment sites in Denmark. The assessment included a point-of-care test for antibodies against SARS-CoV-2, followed by a questionnaire. The seroprevalence was compared to that of geographically matched blood donors considered as a proxy for the background population, tested using a total Ig ELISA assay. Results We included 827 participants in the study, of whom 819 provided their SARS-CoV-2 antibody results. Of those, 628 were PEH (median age 50.8 (IQR 40.9–59.1) years, 35.5% female) and 191 were shelter workers (median age 46.6 (IQR 36.1–55.0) years and 74.5% female). The overall seroprevalence was 6.7% and was similar among PEH and shelter workers (6.8% vs 6.3%, p = 0.87); and 12.2% among all participants who engaged in sex work. The overall participant seroprevalence was significantly higher than that of the background population (2.9%, p < 0.001). When combining all participants who reported sex work or were recruited at designated safe havens, we found a significantly increased risk of seropositivity compared to other participants (OR 2.23, 95%CI 1.06–4.43, p = 0.02). Seropositive and seronegative participants reported a similar presence of at least one SARS-CoV-2 associated symptom (49% and 54%, respectively). Interpretations The prevalence of SARS-CoV-2 antibodies was more than twice as high among PEH and associated shelter workers, compared to the background population. These results could be taken into consideration when deciding in which phase PEH are eligible for a vaccine, as part of the Danish national SARS-CoV-2 vaccination program rollout. Funding TrygFonden and HelseFonden. |
| first_indexed | 2024-12-10T16:51:18Z |
| format | Article |
| id | doaj.art-567304d9bbcf4fe9935e822053b208ab |
| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-12-10T16:51:18Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj.art-567304d9bbcf4fe9935e822053b208ab2022-12-22T01:40:53ZengBMCBMC Public Health1471-24582022-06-0122111310.1186/s12889-022-13642-7SARS-CoV-2 antibody prevalence among homeless people and shelter workers in Denmark: a nationwide cross-sectional studyAlexandra R Röthlin Eriksen0Kamille Fogh1Rasmus B. Hasselbalch2Henning Bundgaard3Susanne D. Nielsen4Charlotte S. Jørgensen5Bibi F. S. S. Scharff6Christian Erikstrup7Susanne G. Sækmose8Dorte K. Holm9Bitten Aagaard10Jonas H. Kristensen11Cecilie A. Bødker12Jakob B. Norsk13Pernille B. Nielsen14Lars Østergaard15Svend Ellermann-Eriksen16Berit Andersen17Henrik Nielsen18Isik S. Johansen19Lothar Wiese20Lone Simonsen21Thea K.Fischer22Fredrik Folke23Freddy Lippert24Sisse R. Ostrowski25Steen Ethelberg26Anders Koch27Anne-Marie Vangsted28Tyra Krause29Anders Fomsgaard30Claus Nielsen31Henrik Ullum32Robert Skov33Kasper Iversen34Department of Cardiology, Copenhagen University Hospital, Herlev and GentofteDepartment of Cardiology, Copenhagen University Hospital, Herlev and GentofteDepartment of Cardiology, Copenhagen University Hospital, Herlev and GentofteDepartment of Clinical Medicine, University of CopenhagenDepartment of Clinical Medicine, University of CopenhagenStatens Serum InstitutDepartment of Clinical Medicine, University of CopenhagenDepartment of Clinical Microbiology, Aarhus University HospitalDepartment of Clinical Medicine, University of CopenhagenDepartment of Clinical Immunology, Odense University HospitalDepartment of Clinical Immunology, Aalborg University HospitalDepartment of Cardiology, Copenhagen University Hospital, Herlev and GentofteDepartment of Cardiology, Copenhagen University Hospital, Herlev and GentofteDepartment of Cardiology, Copenhagen University Hospital, Herlev and GentofteDepartment of Cardiology, Copenhagen University Hospital, Herlev and GentofteDepartment of Infectious Diseases, Aarhus University HospitalDepartment of Clinical Microbiology, Aarhus University HospitalUniversity Research Clinic for Cancer Screening, Randers Regional HospitalDepartment of Infectious Diseases, Aalborg University HospitalDepartment of Research Medicine, University of Southern DenmarkDepartment of Infectious Diseases, Zealand University HospitalDepartment of Science and Environment, University of RoskildeDepartment of Clinical Research, North Zealand HospitalDepartment of Clinical Medicine, University of CopenhagenDepartment of Clinical Medicine, University of CopenhagenDepartment of Clinical Immunology, Copenhagen University Hospital, RigshospitaletStatens Serum InstitutStatens Serum InstitutStatens Serum InstitutStatens Serum InstitutStatens Serum InstitutStatens Serum InstitutStatens Serum InstitutStatens Serum InstitutDepartment of Cardiology, Copenhagen University Hospital, Herlev and GentofteAbstract Background People experiencing homelessness (PEH) and associated shelter workers may be at higher risk of infection with “Severe acute respiratory syndrome coronavirus 2” (SARS-CoV-2). The aim of this study was to determine the prevalence of SARS-CoV-2 among PEH and shelter workers in Denmark. Design and methods In November 2020, we conducted a nationwide cross-sectional seroprevalence study among PEH and shelter workers at 21 recruitment sites in Denmark. The assessment included a point-of-care test for antibodies against SARS-CoV-2, followed by a questionnaire. The seroprevalence was compared to that of geographically matched blood donors considered as a proxy for the background population, tested using a total Ig ELISA assay. Results We included 827 participants in the study, of whom 819 provided their SARS-CoV-2 antibody results. Of those, 628 were PEH (median age 50.8 (IQR 40.9–59.1) years, 35.5% female) and 191 were shelter workers (median age 46.6 (IQR 36.1–55.0) years and 74.5% female). The overall seroprevalence was 6.7% and was similar among PEH and shelter workers (6.8% vs 6.3%, p = 0.87); and 12.2% among all participants who engaged in sex work. The overall participant seroprevalence was significantly higher than that of the background population (2.9%, p < 0.001). When combining all participants who reported sex work or were recruited at designated safe havens, we found a significantly increased risk of seropositivity compared to other participants (OR 2.23, 95%CI 1.06–4.43, p = 0.02). Seropositive and seronegative participants reported a similar presence of at least one SARS-CoV-2 associated symptom (49% and 54%, respectively). Interpretations The prevalence of SARS-CoV-2 antibodies was more than twice as high among PEH and associated shelter workers, compared to the background population. These results could be taken into consideration when deciding in which phase PEH are eligible for a vaccine, as part of the Danish national SARS-CoV-2 vaccination program rollout. Funding TrygFonden and HelseFonden.https://doi.org/10.1186/s12889-022-13642-7 |
| spellingShingle | Alexandra R Röthlin Eriksen Kamille Fogh Rasmus B. Hasselbalch Henning Bundgaard Susanne D. Nielsen Charlotte S. Jørgensen Bibi F. S. S. Scharff Christian Erikstrup Susanne G. Sækmose Dorte K. Holm Bitten Aagaard Jonas H. Kristensen Cecilie A. Bødker Jakob B. Norsk Pernille B. Nielsen Lars Østergaard Svend Ellermann-Eriksen Berit Andersen Henrik Nielsen Isik S. Johansen Lothar Wiese Lone Simonsen Thea K.Fischer Fredrik Folke Freddy Lippert Sisse R. Ostrowski Steen Ethelberg Anders Koch Anne-Marie Vangsted Tyra Krause Anders Fomsgaard Claus Nielsen Henrik Ullum Robert Skov Kasper Iversen SARS-CoV-2 antibody prevalence among homeless people and shelter workers in Denmark: a nationwide cross-sectional study BMC Public Health |
| title | SARS-CoV-2 antibody prevalence among homeless people and shelter workers in Denmark: a nationwide cross-sectional study |
| title_full | SARS-CoV-2 antibody prevalence among homeless people and shelter workers in Denmark: a nationwide cross-sectional study |
| title_fullStr | SARS-CoV-2 antibody prevalence among homeless people and shelter workers in Denmark: a nationwide cross-sectional study |
| title_full_unstemmed | SARS-CoV-2 antibody prevalence among homeless people and shelter workers in Denmark: a nationwide cross-sectional study |
| title_short | SARS-CoV-2 antibody prevalence among homeless people and shelter workers in Denmark: a nationwide cross-sectional study |
| title_sort | sars cov 2 antibody prevalence among homeless people and shelter workers in denmark a nationwide cross sectional study |
| url | https://doi.org/10.1186/s12889-022-13642-7 |
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