Imaging Transcranial Direct Current Stimulation (tDCS) with Positron Emission Tomography (PET)
Transcranial direct current stimulation (tDCS) is a form of non-invasive neuromodulation that is increasingly being utilized to examine and modify several cognitive and motor functions. Although tDCS holds great potential, it is difficult to determine optimal treatment procedures to accommodate conf...
| Үндсэн зохиолчид: | , , , |
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| Формат: | Өгүүллэг |
| Хэл сонгох: | English |
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MDPI AG
2020-04-01
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| Цуврал: | Brain Sciences |
| Нөхцлүүд: | |
| Онлайн хандалт: | https://www.mdpi.com/2076-3425/10/4/236 |
| _version_ | 1827718616662933504 |
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| author | Thorsten Rudroff Craig D. Workman Alexandra C. Fietsam Laura L. Boles Ponto |
| author_facet | Thorsten Rudroff Craig D. Workman Alexandra C. Fietsam Laura L. Boles Ponto |
| author_sort | Thorsten Rudroff |
| collection | DOAJ |
| description | Transcranial direct current stimulation (tDCS) is a form of non-invasive neuromodulation that is increasingly being utilized to examine and modify several cognitive and motor functions. Although tDCS holds great potential, it is difficult to determine optimal treatment procedures to accommodate configurations, the complex shapes, and dramatic conductivity differences among various tissues. Furthermore, recent demonstrations showed that up to 75% of the tDCS current applied to rodents and human cadavers was shunted by the scalp, subcutaneous tissue, and muscle, bringing the effects of tDCS on the cortex into question. Consequently, it is essential to combine tDCS with human neuroimaging to complement animal and cadaver studies and clarify if and how tDCS can affect neural function. One viable approach is positron emission tomography (PET) imaging. PET has unique potential for examining the effects of tDCS within the central nervous system <i>in vivo</i>, including cerebral metabolism, neuroreceptor occupancy, and neurotransmitter activity/binding. The focus of this review is the emerging role of PET and potential PET radiotracers for studying tDCS-induced functional changes in the human brain. |
| first_indexed | 2024-03-10T20:27:03Z |
| format | Article |
| id | doaj.art-56731a2e4fd249898d72023918c04e64 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T20:27:03Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-56731a2e4fd249898d72023918c04e642023-11-19T21:40:31ZengMDPI AGBrain Sciences2076-34252020-04-0110423610.3390/brainsci10040236Imaging Transcranial Direct Current Stimulation (tDCS) with Positron Emission Tomography (PET)Thorsten Rudroff0Craig D. Workman1Alexandra C. Fietsam2Laura L. Boles Ponto3Department of Health and Human Physiology, University of Iowa, Iowa City, IA 52242, USADepartment of Health and Human Physiology, University of Iowa, Iowa City, IA 52242, USADepartment of Health and Human Physiology, University of Iowa, Iowa City, IA 52242, USADepartment of Radiology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USATranscranial direct current stimulation (tDCS) is a form of non-invasive neuromodulation that is increasingly being utilized to examine and modify several cognitive and motor functions. Although tDCS holds great potential, it is difficult to determine optimal treatment procedures to accommodate configurations, the complex shapes, and dramatic conductivity differences among various tissues. Furthermore, recent demonstrations showed that up to 75% of the tDCS current applied to rodents and human cadavers was shunted by the scalp, subcutaneous tissue, and muscle, bringing the effects of tDCS on the cortex into question. Consequently, it is essential to combine tDCS with human neuroimaging to complement animal and cadaver studies and clarify if and how tDCS can affect neural function. One viable approach is positron emission tomography (PET) imaging. PET has unique potential for examining the effects of tDCS within the central nervous system <i>in vivo</i>, including cerebral metabolism, neuroreceptor occupancy, and neurotransmitter activity/binding. The focus of this review is the emerging role of PET and potential PET radiotracers for studying tDCS-induced functional changes in the human brain.https://www.mdpi.com/2076-3425/10/4/236tDCSpositron emission tomographyradiotracerscortical excitability |
| spellingShingle | Thorsten Rudroff Craig D. Workman Alexandra C. Fietsam Laura L. Boles Ponto Imaging Transcranial Direct Current Stimulation (tDCS) with Positron Emission Tomography (PET) Brain Sciences tDCS positron emission tomography radiotracers cortical excitability |
| title | Imaging Transcranial Direct Current Stimulation (tDCS) with Positron Emission Tomography (PET) |
| title_full | Imaging Transcranial Direct Current Stimulation (tDCS) with Positron Emission Tomography (PET) |
| title_fullStr | Imaging Transcranial Direct Current Stimulation (tDCS) with Positron Emission Tomography (PET) |
| title_full_unstemmed | Imaging Transcranial Direct Current Stimulation (tDCS) with Positron Emission Tomography (PET) |
| title_short | Imaging Transcranial Direct Current Stimulation (tDCS) with Positron Emission Tomography (PET) |
| title_sort | imaging transcranial direct current stimulation tdcs with positron emission tomography pet |
| topic | tDCS positron emission tomography radiotracers cortical excitability |
| url | https://www.mdpi.com/2076-3425/10/4/236 |
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