Admixture analysis to define late onset Parkinson’s disease: Moderating effect of the APOE gene
Early onset has been implicated in clinical severity of sporadic Parkinson's Disease (PD) in many populations. PD onset is an important prognostic factor since the continuing neurodegeneration of PD is associated with cognitive deficit. The aim of this study is to analyze the age at onset (AAO)...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-03-01
|
| Series: | Psychiatry Research Communications |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772598722000757 |
| _version_ | 1811157873431937024 |
|---|---|
| author | Vincenzo De Luca Giuseppe Nicoletti Monica Gagliardi Radha Procopio Grazia Annesi |
| author_facet | Vincenzo De Luca Giuseppe Nicoletti Monica Gagliardi Radha Procopio Grazia Annesi |
| author_sort | Vincenzo De Luca |
| collection | DOAJ |
| description | Early onset has been implicated in clinical severity of sporadic Parkinson's Disease (PD) in many populations. PD onset is an important prognostic factor since the continuing neurodegeneration of PD is associated with cognitive deficit. The aim of this study is to analyze the age at onset (AAO) and cognitive deficit of PD in regards of the APOE gene. We investigated the AAO in a sample of 393 sporadic Parkinson's cases from Southern Italy. The admixture analysis highlighted the presence of two onset subgroups in our PD sample. Our analysis of early onset Parkinson's disease confirms the effect on more severe memory deficit in subjects with anticipated onset mediated by the APOE e4 (beta = −0.47; p = 0.02). Our study implicates the effect of e4 allele in susceptibility to cognitive symptoms in late onset PD. Even though our results are preliminary the APOE e4 allele may represent a moderating factor for cognitive deficit and anticipation in late onset PD patients. |
| first_indexed | 2024-04-10T05:14:50Z |
| format | Article |
| id | doaj.art-56763ff6b5f34c5aa9bf9543f05e9bee |
| institution | Directory Open Access Journal |
| issn | 2772-5987 |
| language | English |
| last_indexed | 2024-04-10T05:14:50Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Psychiatry Research Communications |
| spelling | doaj.art-56763ff6b5f34c5aa9bf9543f05e9bee2023-03-09T04:13:59ZengElsevierPsychiatry Research Communications2772-59872023-03-0131100094Admixture analysis to define late onset Parkinson’s disease: Moderating effect of the APOE geneVincenzo De Luca0Giuseppe Nicoletti1Monica Gagliardi2Radha Procopio3Grazia Annesi4CAMH, Toronto, Canada; Corresponding author. Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 250 College St, Toronto, ON, M5T 1R8, Canada.Institute of Molecular Bioimaging and Physiology, National Research Council, Section of Germaneto, Catanzaro, ItalyDepartment of Medical and Surgical Sciences, Neuroscience Research Center, Magna Graecia University, viale Europa, Catanzaro, ItalyInstitute of Molecular Bioimaging and Physiology, National Research Council, Section of Germaneto, Catanzaro, ItalyNational Research Council, Istituto per la Ricerca e l'innovazione Biomedica (IRIB), ItalyEarly onset has been implicated in clinical severity of sporadic Parkinson's Disease (PD) in many populations. PD onset is an important prognostic factor since the continuing neurodegeneration of PD is associated with cognitive deficit. The aim of this study is to analyze the age at onset (AAO) and cognitive deficit of PD in regards of the APOE gene. We investigated the AAO in a sample of 393 sporadic Parkinson's cases from Southern Italy. The admixture analysis highlighted the presence of two onset subgroups in our PD sample. Our analysis of early onset Parkinson's disease confirms the effect on more severe memory deficit in subjects with anticipated onset mediated by the APOE e4 (beta = −0.47; p = 0.02). Our study implicates the effect of e4 allele in susceptibility to cognitive symptoms in late onset PD. Even though our results are preliminary the APOE e4 allele may represent a moderating factor for cognitive deficit and anticipation in late onset PD patients.http://www.sciencedirect.com/science/article/pii/S2772598722000757Parkinson's diseaseGeneticsAPOEAge at onsetAdmixture analysis |
| spellingShingle | Vincenzo De Luca Giuseppe Nicoletti Monica Gagliardi Radha Procopio Grazia Annesi Admixture analysis to define late onset Parkinson’s disease: Moderating effect of the APOE gene Psychiatry Research Communications Parkinson's disease Genetics APOE Age at onset Admixture analysis |
| title | Admixture analysis to define late onset Parkinson’s disease: Moderating effect of the APOE gene |
| title_full | Admixture analysis to define late onset Parkinson’s disease: Moderating effect of the APOE gene |
| title_fullStr | Admixture analysis to define late onset Parkinson’s disease: Moderating effect of the APOE gene |
| title_full_unstemmed | Admixture analysis to define late onset Parkinson’s disease: Moderating effect of the APOE gene |
| title_short | Admixture analysis to define late onset Parkinson’s disease: Moderating effect of the APOE gene |
| title_sort | admixture analysis to define late onset parkinson s disease moderating effect of the apoe gene |
| topic | Parkinson's disease Genetics APOE Age at onset Admixture analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2772598722000757 |
| work_keys_str_mv | AT vincenzodeluca admixtureanalysistodefinelateonsetparkinsonsdiseasemoderatingeffectoftheapoegene AT giuseppenicoletti admixtureanalysistodefinelateonsetparkinsonsdiseasemoderatingeffectoftheapoegene AT monicagagliardi admixtureanalysistodefinelateonsetparkinsonsdiseasemoderatingeffectoftheapoegene AT radhaprocopio admixtureanalysistodefinelateonsetparkinsonsdiseasemoderatingeffectoftheapoegene AT graziaannesi admixtureanalysistodefinelateonsetparkinsonsdiseasemoderatingeffectoftheapoegene |