Selenium Nanoparticles Control H1N1 Virus by Inhibiting Inflammatory Response and Cell Apoptosis
The treatment of influenza caused by H1N1 has been the focus of much attention. Selenium nanoparticles (SeNPs) have been used in many aspects of research in the last two decades. They have shown excellent performance in antiviral, anti-inflammatory, and antioxidant functions. Previous anti-H1N1 cell...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/15/5920 |
| _version_ | 1797586226284331008 |
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| author | Jingyao Su Jia Lai Jiali Li Chuqing Li Xia Liu Chenyang Wang Bing Zhu Yinghua Li |
| author_facet | Jingyao Su Jia Lai Jiali Li Chuqing Li Xia Liu Chenyang Wang Bing Zhu Yinghua Li |
| author_sort | Jingyao Su |
| collection | DOAJ |
| description | The treatment of influenza caused by H1N1 has been the focus of much attention. Selenium nanoparticles (SeNPs) have been used in many aspects of research in the last two decades. They have shown excellent performance in antiviral, anti-inflammatory, and antioxidant functions. Previous anti-H1N1 cell experiments using SeNPs have shown that they have evident antiviral effects and low toxicities. This study focuses on the mechanism of selenium nanoparticles against an H1N1 influenza virus infection in vivo. The results showed that the selenium levels in the body decreased after an H1N1 virus infection, and inflammatory factors in the lung tissues increased abnormally, leading to the onset and aggravation of an inflammatory response. The H1N1 virus infection also led to the excessive activation of apoptotic pathways in the body and induced the apoptosis of tissue cells. In addition, this study found that SeNPs can alleviate this phenomenon. All results showed that SeNPs are promising inhibitors for controlling influenza H1N1 virus infections. |
| first_indexed | 2024-03-11T00:20:26Z |
| format | Article |
| id | doaj.art-567757f3856042fe9572e66dec08b0ec |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T00:20:26Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-567757f3856042fe9572e66dec08b0ec2023-11-18T23:20:38ZengMDPI AGMolecules1420-30492023-08-012815592010.3390/molecules28155920Selenium Nanoparticles Control H1N1 Virus by Inhibiting Inflammatory Response and Cell ApoptosisJingyao Su0Jia Lai1Jiali Li2Chuqing Li3Xia Liu4Chenyang Wang5Bing Zhu6Yinghua Li7Center Laboratory, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510120, ChinaCenter Laboratory, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510120, ChinaCenter Laboratory, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510120, ChinaCenter Laboratory, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510120, ChinaCenter Laboratory, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510120, ChinaCenter Laboratory, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510120, ChinaCenter Laboratory, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510120, ChinaCenter Laboratory, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510120, ChinaThe treatment of influenza caused by H1N1 has been the focus of much attention. Selenium nanoparticles (SeNPs) have been used in many aspects of research in the last two decades. They have shown excellent performance in antiviral, anti-inflammatory, and antioxidant functions. Previous anti-H1N1 cell experiments using SeNPs have shown that they have evident antiviral effects and low toxicities. This study focuses on the mechanism of selenium nanoparticles against an H1N1 influenza virus infection in vivo. The results showed that the selenium levels in the body decreased after an H1N1 virus infection, and inflammatory factors in the lung tissues increased abnormally, leading to the onset and aggravation of an inflammatory response. The H1N1 virus infection also led to the excessive activation of apoptotic pathways in the body and induced the apoptosis of tissue cells. In addition, this study found that SeNPs can alleviate this phenomenon. All results showed that SeNPs are promising inhibitors for controlling influenza H1N1 virus infections.https://www.mdpi.com/1420-3049/28/15/5920SeNPsH1N1inflammationapoptosis |
| spellingShingle | Jingyao Su Jia Lai Jiali Li Chuqing Li Xia Liu Chenyang Wang Bing Zhu Yinghua Li Selenium Nanoparticles Control H1N1 Virus by Inhibiting Inflammatory Response and Cell Apoptosis Molecules SeNPs H1N1 inflammation apoptosis |
| title | Selenium Nanoparticles Control H1N1 Virus by Inhibiting Inflammatory Response and Cell Apoptosis |
| title_full | Selenium Nanoparticles Control H1N1 Virus by Inhibiting Inflammatory Response and Cell Apoptosis |
| title_fullStr | Selenium Nanoparticles Control H1N1 Virus by Inhibiting Inflammatory Response and Cell Apoptosis |
| title_full_unstemmed | Selenium Nanoparticles Control H1N1 Virus by Inhibiting Inflammatory Response and Cell Apoptosis |
| title_short | Selenium Nanoparticles Control H1N1 Virus by Inhibiting Inflammatory Response and Cell Apoptosis |
| title_sort | selenium nanoparticles control h1n1 virus by inhibiting inflammatory response and cell apoptosis |
| topic | SeNPs H1N1 inflammation apoptosis |
| url | https://www.mdpi.com/1420-3049/28/15/5920 |
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