Selection of potential natural compounds for poly-ADP-ribose polymerase (PARP) inhibition in glioblastoma therapy by in silico screening methods

Selection of potential natural compounds for poly-ADP-ribose polymerase (PARP) inhibition in glioblastoma therapy by in silico screening methods

Glioblastoma (GBM), the most prevalent brain tumor, is one of the least treatable malignancies due to its propensity for intracranial spread, high proliferative potential, and innate resistance to radiation and chemotherapy. Current GBM therapy is limited due to unfavorable, non-specific therapeutic...

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Bibliographic Details
Main Authors: Arunraj Tharamelveliyil Rajendran, Gupta Dheeraj Rajesh, Pankaj Kumar, Prarambh Shivam Raju Dwivedi, Chakrakodi Shashidhara Shastry, Anoop Narayanan Vadakkepushpakath
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Saudi Journal of Biological Sciences
Subjects:
PARP inhibitors
Cancer
Phytomedicines
In silico
Pharmacophore
Molecular Dynamic Simulation
Online Access:http://www.sciencedirect.com/science/article/pii/S1319562X23001432

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