Leptin therapy, insulin sensitivity, and glucose homeostasis
Glucose homeostasis is closely regulated not only by insulin, but also by leptin. Both hormones act centrally, regulating food intake and adiposity in humans. Leptin has several effects on the glucose-insulin homeostasis, some of which are independent of body weight and adiposity. Those effects of l...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2012-01-01
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| Series: | Indian Journal of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2012;volume=16;issue=9;spage=549;epage=555;aulast=Paz-Filho |
| _version_ | 1819195424245809152 |
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| author | Gilberto Paz-Filho Claudio Mastronardi Ma-Li Wong Julio Licinio |
| author_facet | Gilberto Paz-Filho Claudio Mastronardi Ma-Li Wong Julio Licinio |
| author_sort | Gilberto Paz-Filho |
| collection | DOAJ |
| description | Glucose homeostasis is closely regulated not only by insulin, but also by leptin. Both hormones act centrally, regulating food intake and adiposity in humans. Leptin has several effects on the glucose-insulin homeostasis, some of which are independent of body weight and adiposity. Those effects of leptin are determined centrally in the hypothalamus and peripherally in the pancreas, muscles and liver. Leptin has beneficial effects on the glucose-insulin metabolism, by decreasing glycemia, insulinemia and insulin resistance. The understanding of the effects of leptin on the glucose-insulin homeostasis will lead to the development of leptin-based therapies against diabetes and other insulin resistance syndromes. In these review, we summarize the interactions between leptin and insulin, and their effects on the glucose metabolism. |
| first_indexed | 2024-12-23T02:12:32Z |
| format | Article |
| id | doaj.art-567963cd497c4f8d91990eab64e06461 |
| institution | Directory Open Access Journal |
| issn | 2230-8210 2230-9500 |
| language | English |
| last_indexed | 2024-12-23T02:12:32Z |
| publishDate | 2012-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-567963cd497c4f8d91990eab64e064612022-12-21T18:03:45ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102230-95002012-01-0116954955510.4103/2230-8210.105571Leptin therapy, insulin sensitivity, and glucose homeostasisGilberto Paz-FilhoClaudio MastronardiMa-Li WongJulio LicinioGlucose homeostasis is closely regulated not only by insulin, but also by leptin. Both hormones act centrally, regulating food intake and adiposity in humans. Leptin has several effects on the glucose-insulin homeostasis, some of which are independent of body weight and adiposity. Those effects of leptin are determined centrally in the hypothalamus and peripherally in the pancreas, muscles and liver. Leptin has beneficial effects on the glucose-insulin metabolism, by decreasing glycemia, insulinemia and insulin resistance. The understanding of the effects of leptin on the glucose-insulin homeostasis will lead to the development of leptin-based therapies against diabetes and other insulin resistance syndromes. In these review, we summarize the interactions between leptin and insulin, and their effects on the glucose metabolism.http://www.ijem.in/article.asp?issn=2230-8210;year=2012;volume=16;issue=9;spage=549;epage=555;aulast=Paz-FilhoDiabetesglucoseinsulininsulin resistanceleptin |
| spellingShingle | Gilberto Paz-Filho Claudio Mastronardi Ma-Li Wong Julio Licinio Leptin therapy, insulin sensitivity, and glucose homeostasis Indian Journal of Endocrinology and Metabolism Diabetes glucose insulin insulin resistance leptin |
| title | Leptin therapy, insulin sensitivity, and glucose homeostasis |
| title_full | Leptin therapy, insulin sensitivity, and glucose homeostasis |
| title_fullStr | Leptin therapy, insulin sensitivity, and glucose homeostasis |
| title_full_unstemmed | Leptin therapy, insulin sensitivity, and glucose homeostasis |
| title_short | Leptin therapy, insulin sensitivity, and glucose homeostasis |
| title_sort | leptin therapy insulin sensitivity and glucose homeostasis |
| topic | Diabetes glucose insulin insulin resistance leptin |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2012;volume=16;issue=9;spage=549;epage=555;aulast=Paz-Filho |
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