Myostatin Mutation Promotes Glycolysis by Increasing Phosphorylation of Phosphofructokinase via Activation of PDE5A-cGMP-PKG in Cattle Heart

Myostatin Mutation Promotes Glycolysis by Increasing Phosphorylation of Phosphofructokinase via Activation of PDE5A-cGMP-PKG in Cattle Heart

Myostatin (MSTN) is a primary negative regulator of skeletal muscle mass and causes multiple metabolic changes. However, whether MSTN mutation affects heart morphology and physiology remains unclear. Myostatin mutation (MT) had no effect on cattle cardiac muscle in histological examination, but in b...

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Bibliographic Details
Main Authors: Mingjuan Gu, Xinyu Zhou, Lin Zhu, Yajie Gao, Li Gao, Chunling Bai, Lei Yang, Guangpeng Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
heart
glycolysis
PDE5A-cGMP-PKG
phosphofructokinase
myostatin mutation
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.774185/full

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