Interferon (IFN) and Cellular Immune Response Evoked in RNA-Pattern Sensing During Infection with Hepatitis C Virus (HCV)

Interferon (IFN) and Cellular Immune Response Evoked in RNA-Pattern Sensing During Infection with Hepatitis C Virus (HCV)

Hepatitis C virus (HCV) infects hepatocytes but not dendritic cells (DCs), but DCs effectively mature in response to HCV-infected hepatocytes. Using gene-disrupted mice and hydrodynamic injection strategy, we found the MAVS pathway to be crucial for induction of type III interferons (IFNs) in respon...

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Bibliographic Details
Main Authors:	Masato Nakai, Hiroyuki Oshiumi, Kenji Funami, Masaaki Okamoto, Misako Matsumoto, Tsukasa Seya, Naoya Sakamoto
Format:	Article
Language:	English
Published:	MDPI AG 2015-10-01
Series:	Sensors
Subjects:	Hepatitis C virus (HCV) interferon (IFN)-lambda dendritic cells (DCs) Toll-like receptor 3 (TLR3) natural killer (NK) cell cytotoxic T lymphocyte (CTL)
Online Access:	http://www.mdpi.com/1424-8220/15/10/27160

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