The semiquinone swing in the bifurcating electron transferring flavoprotein/butyryl-CoA dehydrogenase complex from Clostridium difficile
The electron-transferring flavoprotein / butyryl-CoA dehydrogenase (EtfAB/Bcd) complex catalyzes the reduction of crotonyl-CoA and ferredoxins by NADH in anaerobic microbes. Here, the authors present the crystal structure of Clostridium difficile EtfAB/Bcd and discuss the bifurcation mechanism for e...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-11-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-01746-3 |
| _version_ | 1818433672298102784 |
|---|---|
| author | Julius K. Demmer Nilanjan Pal Chowdhury Thorsten Selmer Ulrich Ermler Wolfgang Buckel |
| author_facet | Julius K. Demmer Nilanjan Pal Chowdhury Thorsten Selmer Ulrich Ermler Wolfgang Buckel |
| author_sort | Julius K. Demmer |
| collection | DOAJ |
| description | The electron-transferring flavoprotein / butyryl-CoA dehydrogenase (EtfAB/Bcd) complex catalyzes the reduction of crotonyl-CoA and ferredoxins by NADH in anaerobic microbes. Here, the authors present the crystal structure of Clostridium difficile EtfAB/Bcd and discuss the bifurcation mechanism for electron flow. |
| first_indexed | 2024-12-14T16:24:49Z |
| format | Article |
| id | doaj.art-5682c72d8b5c4535ae81aa69d64ef9a2 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T16:24:49Z |
| publishDate | 2017-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-5682c72d8b5c4535ae81aa69d64ef9a22022-12-21T22:54:42ZengNature PortfolioNature Communications2041-17232017-11-018111010.1038/s41467-017-01746-3The semiquinone swing in the bifurcating electron transferring flavoprotein/butyryl-CoA dehydrogenase complex from Clostridium difficileJulius K. Demmer0Nilanjan Pal Chowdhury1Thorsten Selmer2Ulrich Ermler3Wolfgang Buckel4Max-Planck-Institut für BiophysikLaboratorium für Mikrobiologie, Fachbereich Biologie and SYNMIKRO, Philipps-UniversitätFachbereich Chemie und Biotechnologie, FH AachenMax-Planck-Institut für BiophysikLaboratorium für Mikrobiologie, Fachbereich Biologie and SYNMIKRO, Philipps-UniversitätThe electron-transferring flavoprotein / butyryl-CoA dehydrogenase (EtfAB/Bcd) complex catalyzes the reduction of crotonyl-CoA and ferredoxins by NADH in anaerobic microbes. Here, the authors present the crystal structure of Clostridium difficile EtfAB/Bcd and discuss the bifurcation mechanism for electron flow.https://doi.org/10.1038/s41467-017-01746-3 |
| spellingShingle | Julius K. Demmer Nilanjan Pal Chowdhury Thorsten Selmer Ulrich Ermler Wolfgang Buckel The semiquinone swing in the bifurcating electron transferring flavoprotein/butyryl-CoA dehydrogenase complex from Clostridium difficile Nature Communications |
| title | The semiquinone swing in the bifurcating electron transferring flavoprotein/butyryl-CoA dehydrogenase complex from Clostridium difficile |
| title_full | The semiquinone swing in the bifurcating electron transferring flavoprotein/butyryl-CoA dehydrogenase complex from Clostridium difficile |
| title_fullStr | The semiquinone swing in the bifurcating electron transferring flavoprotein/butyryl-CoA dehydrogenase complex from Clostridium difficile |
| title_full_unstemmed | The semiquinone swing in the bifurcating electron transferring flavoprotein/butyryl-CoA dehydrogenase complex from Clostridium difficile |
| title_short | The semiquinone swing in the bifurcating electron transferring flavoprotein/butyryl-CoA dehydrogenase complex from Clostridium difficile |
| title_sort | semiquinone swing in the bifurcating electron transferring flavoprotein butyryl coa dehydrogenase complex from clostridium difficile |
| url | https://doi.org/10.1038/s41467-017-01746-3 |
| work_keys_str_mv | AT juliuskdemmer thesemiquinoneswinginthebifurcatingelectrontransferringflavoproteinbutyrylcoadehydrogenasecomplexfromclostridiumdifficile AT nilanjanpalchowdhury thesemiquinoneswinginthebifurcatingelectrontransferringflavoproteinbutyrylcoadehydrogenasecomplexfromclostridiumdifficile AT thorstenselmer thesemiquinoneswinginthebifurcatingelectrontransferringflavoproteinbutyrylcoadehydrogenasecomplexfromclostridiumdifficile AT ulrichermler thesemiquinoneswinginthebifurcatingelectrontransferringflavoproteinbutyrylcoadehydrogenasecomplexfromclostridiumdifficile AT wolfgangbuckel thesemiquinoneswinginthebifurcatingelectrontransferringflavoproteinbutyrylcoadehydrogenasecomplexfromclostridiumdifficile AT juliuskdemmer semiquinoneswinginthebifurcatingelectrontransferringflavoproteinbutyrylcoadehydrogenasecomplexfromclostridiumdifficile AT nilanjanpalchowdhury semiquinoneswinginthebifurcatingelectrontransferringflavoproteinbutyrylcoadehydrogenasecomplexfromclostridiumdifficile AT thorstenselmer semiquinoneswinginthebifurcatingelectrontransferringflavoproteinbutyrylcoadehydrogenasecomplexfromclostridiumdifficile AT ulrichermler semiquinoneswinginthebifurcatingelectrontransferringflavoproteinbutyrylcoadehydrogenasecomplexfromclostridiumdifficile AT wolfgangbuckel semiquinoneswinginthebifurcatingelectrontransferringflavoproteinbutyrylcoadehydrogenasecomplexfromclostridiumdifficile |