Pharmacological inhibition of mTORC1 reduces neural death and damage volume after MCAO by modulating microglial reactivity

Pharmacological inhibition of mTORC1 reduces neural death and damage volume after MCAO by modulating microglial reactivity

Abstract Ischemic stroke is a sudden and acute disease characterized by neuronal death, increment of reactive gliosis (reactive microglia and astrocytes), and a severe inflammatory process. Neuroinflammation is an early event after cerebral ischemia, with microglia playing a leading role. Reactive m...

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Bibliographic Details
Main Authors: Mario Villa-González, Marina Rubio, Gerardo Martín-López, Paula R. Mallavibarrena, Laura Vallés-Saiz, Denis Vivien, Francisco Wandosell, Maria José Pérez-Álvarez
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Biology Direct
Subjects:
Astrocytes
Cerebral ischemia
Glia
MCAO
Microglia
mTORC1
Online Access:https://doi.org/10.1186/s13062-024-00470-5

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