Construction of magnetic nanochains to achieve magnetic energy coupling in scaffold
Abstract Background Fe3O4 nanoparticles are highly desired for constructing endogenous magnetic microenvironment in scaffold to accelerate bone regeneration due to their superior magnetism. However, their random arrangement easily leads to mutual consumption of magnetic poles, thereby weakening the...
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| Format: | Article |
| Language: | English |
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American Association for the Advancement of Science (AAAS)
2022-08-01
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| Series: | Biomaterials Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40824-022-00278-2 |
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| author | Cijun Shuai Xuan Chen Chongxian He Guowen Qian Yang Shuai Shuping Peng Youwen Deng Wenjing Yang |
| author_facet | Cijun Shuai Xuan Chen Chongxian He Guowen Qian Yang Shuai Shuping Peng Youwen Deng Wenjing Yang |
| author_sort | Cijun Shuai |
| collection | DOAJ |
| description | Abstract Background Fe3O4 nanoparticles are highly desired for constructing endogenous magnetic microenvironment in scaffold to accelerate bone regeneration due to their superior magnetism. However, their random arrangement easily leads to mutual consumption of magnetic poles, thereby weakening the magnetic stimulation effect. Methods In this study, magnetic nanochains are synthesized by magnetic-field-guided interface co-assembly of Fe3O4 nanoparticles. In detail, multiple Fe3O4 nanoparticles are aligned along the direction of magnetic force lines and are connected in series to form nanochain structures under an external magnetic field. Subsequently, the nanochain structures are covered and fixed by depositing a thin layer of silica (SiO2), and consequently forming linear magnetic nanochains (Fe3O4@SiO2). The Fe3O4@SiO2 nanochains are then incorporated into poly l-lactic acid (PLLA) scaffold prepared by selective laser sintering technology. Results The results show that the Fe3O4@SiO2 nanochains with unique core–shell structure are successfully constructed. Meanwhile, the orderly assembly of nanoparticles in the Fe3O4@SiO2 nanochains enable to form magnetic energy coupling and obtain a highly magnetic micro-field. The in vitro tests indicate that the PLLA/Fe3O4@SiO2 scaffolds exhibit superior capacity in enhancing cell activity, improving osteogenesis-related gene expressions, and inducing cell mineralization compared with PLLA and PLLA/Fe3O4 scaffolds. Conclusion In short, the Fe3O4@SiO2 nanochains endow scaffolds with good magnetism and cytocompatibility, which have great potential in accelerating bone repair. |
| first_indexed | 2024-03-07T18:28:55Z |
| format | Article |
| id | doaj.art-568622234767435dbec25c55420cb757 |
| institution | Directory Open Access Journal |
| issn | 2055-7124 |
| language | English |
| last_indexed | 2024-03-07T18:28:55Z |
| publishDate | 2022-08-01 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | Article |
| series | Biomaterials Research |
| spelling | doaj.art-568622234767435dbec25c55420cb7572024-03-02T06:45:14ZengAmerican Association for the Advancement of Science (AAAS)Biomaterials Research2055-71242022-08-0126111310.1186/s40824-022-00278-2Construction of magnetic nanochains to achieve magnetic energy coupling in scaffoldCijun Shuai0Xuan Chen1Chongxian He2Guowen Qian3Yang Shuai4Shuping Peng5Youwen Deng6Wenjing Yang7Institute of Additive Manufacturing, Jiangxi University of Science and TechnologyInstitute of Additive Manufacturing, Jiangxi University of Science and TechnologyState Key Laboratory of High Performance Complex Manufacturing, Central South UniversityInstitute of Additive Manufacturing, Jiangxi University of Science and TechnologyCollege of Life Science and Technology, Huazhong University of Science and TechnologyThe Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Xiangya Hospital, Central South UniversityDepartment of Spine Surgery, Third Xiangya Hospital, Central South UniversityInstitute of Additive Manufacturing, Jiangxi University of Science and TechnologyAbstract Background Fe3O4 nanoparticles are highly desired for constructing endogenous magnetic microenvironment in scaffold to accelerate bone regeneration due to their superior magnetism. However, their random arrangement easily leads to mutual consumption of magnetic poles, thereby weakening the magnetic stimulation effect. Methods In this study, magnetic nanochains are synthesized by magnetic-field-guided interface co-assembly of Fe3O4 nanoparticles. In detail, multiple Fe3O4 nanoparticles are aligned along the direction of magnetic force lines and are connected in series to form nanochain structures under an external magnetic field. Subsequently, the nanochain structures are covered and fixed by depositing a thin layer of silica (SiO2), and consequently forming linear magnetic nanochains (Fe3O4@SiO2). The Fe3O4@SiO2 nanochains are then incorporated into poly l-lactic acid (PLLA) scaffold prepared by selective laser sintering technology. Results The results show that the Fe3O4@SiO2 nanochains with unique core–shell structure are successfully constructed. Meanwhile, the orderly assembly of nanoparticles in the Fe3O4@SiO2 nanochains enable to form magnetic energy coupling and obtain a highly magnetic micro-field. The in vitro tests indicate that the PLLA/Fe3O4@SiO2 scaffolds exhibit superior capacity in enhancing cell activity, improving osteogenesis-related gene expressions, and inducing cell mineralization compared with PLLA and PLLA/Fe3O4 scaffolds. Conclusion In short, the Fe3O4@SiO2 nanochains endow scaffolds with good magnetism and cytocompatibility, which have great potential in accelerating bone repair.https://doi.org/10.1186/s40824-022-00278-2Magnetic microenvironmentFe3O4 nanoparticlesMagnetic nanochainsMagnetic energy couplingBone scaffold |
| spellingShingle | Cijun Shuai Xuan Chen Chongxian He Guowen Qian Yang Shuai Shuping Peng Youwen Deng Wenjing Yang Construction of magnetic nanochains to achieve magnetic energy coupling in scaffold Biomaterials Research Magnetic microenvironment Fe3O4 nanoparticles Magnetic nanochains Magnetic energy coupling Bone scaffold |
| title | Construction of magnetic nanochains to achieve magnetic energy coupling in scaffold |
| title_full | Construction of magnetic nanochains to achieve magnetic energy coupling in scaffold |
| title_fullStr | Construction of magnetic nanochains to achieve magnetic energy coupling in scaffold |
| title_full_unstemmed | Construction of magnetic nanochains to achieve magnetic energy coupling in scaffold |
| title_short | Construction of magnetic nanochains to achieve magnetic energy coupling in scaffold |
| title_sort | construction of magnetic nanochains to achieve magnetic energy coupling in scaffold |
| topic | Magnetic microenvironment Fe3O4 nanoparticles Magnetic nanochains Magnetic energy coupling Bone scaffold |
| url | https://doi.org/10.1186/s40824-022-00278-2 |
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