Identification of a potent NAFLD drug candidate for controlling T2DM-mediated inflammation and secondary damage in vitro and in vivo

Identification of a potent NAFLD drug candidate for controlling T2DM-mediated inflammation and secondary damage in vitro and in vivo

Accumulation of glucose/sugar results in the formation of reactive di-carbonyl compounds such as MGO and GO that interact with several amino acids and proteins to form toxic advanced glycation end products (AGEs). Induction of AGEs breakdown can control symptoms and severity in T2DM and other relate...

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Bibliographic Details
Main Authors: Md Samsuzzaman, Jae Hyuk Lee, Hyejin Moon, Jisue Lee, Heaji Lee, Yunsook Lim, Myoung Gyu Park, Hakwon Kim, Sun Yeou Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Pharmacology
Subjects:
glucotoxicity
NASH
KHAG-04
inflammation
lipogenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.943879/full

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