Insulin resistance is related to cognitive decline but not change in CSF biomarkers of Alzheimer's disease in non‐demented adults

Insulin resistance is related to cognitive decline but not change in CSF biomarkers of Alzheimer's disease in non‐demented adults

Abstract Introduction We investigated whether insulin resistance (IR) was associated with longitudinal age‐related change in cognition and biomarkers of Alzheimer's disease (AD) pathology and neurodegeneration in middle‐aged and older adults who were non‐demented at baseline. Methods IR was mea...

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Bibliographic Details
Main Authors: Gilda E. Ennis, Rebecca L. Koscik, Yue Ma, Erin M. Jonaitis, Carol A. Van Hulle, Tobey J. Betthauser, Allison M. Randall, Nathaniel Chin, Corinne D. Engelman, Rozalyn Anderson, Ivonne Suridjan, Gwendlyn Kollmorgen, Bradley T. Christian, Cynthia M. Carlsson, Sanjay Asthana, Sterling C. Johnson, Henrik Zetterberg, Kaj Blennow, Barbara B. Bendlin
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Subjects:
APOE4
cognition
CSF biomarkers
insulin resistance
neurodegeneration
p‐tau181
Online Access:https://doi.org/10.1002/dad2.12220

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