The Consistencies of Y-Chromosomal and Autosomal Continental Ancestry Varying among Haplogroups
The Y-chromosome has been widely used in ancestry inference based on its region-specific haplogroup distributions. However, there is always a debate on how informative such a single marker is for inferring an individual's genetic ancestry. Here, we compared genetic ancestry inferences at contin...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Journal of Forensic Science and Medicine |
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| Online Access: | http://www.jfsmonline.com/article.asp?issn=2349-5014;year=2016;volume=2;issue=4;spage=229;epage=232;aulast=Wang |
| _version_ | 1811272073868214272 |
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| author | Chuan-Chao Wang Lei Shang Hui-Yuan Yeh Lan-Hai Wei |
| author_facet | Chuan-Chao Wang Lei Shang Hui-Yuan Yeh Lan-Hai Wei |
| author_sort | Chuan-Chao Wang |
| collection | DOAJ |
| description | The Y-chromosome has been widely used in ancestry inference based on its region-specific haplogroup distributions. However, there is always a debate on how informative such a single marker is for inferring an individual's genetic ancestry. Here, we compared genetic ancestry inferences at continental level made by Y-chromosomal haplogroups to those made by autosomal single-nucleotide polymorphisms in 1230 samples of Affymetrix Human Origins dataset. The highest ancestry proportions of a majority of individuals match the highest average continental-ancestry proportions in haplogroups A, B, D, H, I, K, L, T, O, and M. The high consistencies have not been observed in haplogroups E, C, G, J, N, Q, and R, but in some of their sublineages, such as E1a, E1b1a1, E1b1b1b1a, E2b1a, J1a2b, Q1a1a1, Q1a2a1a1, R1b1a2a1a, and R2. Although the consistencies of Y-chromosomal and autosomal continental ancestry vary among haplogroups, Y-chromosome could provide valuable clues for individual's continental ancestry. |
| first_indexed | 2024-04-12T22:33:52Z |
| format | Article |
| id | doaj.art-5688034af201460a8eba90e8e53e5bc6 |
| institution | Directory Open Access Journal |
| issn | 2349-5014 |
| language | English |
| last_indexed | 2024-04-12T22:33:52Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Forensic Science and Medicine |
| spelling | doaj.art-5688034af201460a8eba90e8e53e5bc62022-12-22T03:13:54ZengWolters Kluwer Medknow PublicationsJournal of Forensic Science and Medicine2349-50142016-01-012422923210.4103/2349-5014.197925The Consistencies of Y-Chromosomal and Autosomal Continental Ancestry Varying among HaplogroupsChuan-Chao WangLei ShangHui-Yuan YehLan-Hai WeiThe Y-chromosome has been widely used in ancestry inference based on its region-specific haplogroup distributions. However, there is always a debate on how informative such a single marker is for inferring an individual's genetic ancestry. Here, we compared genetic ancestry inferences at continental level made by Y-chromosomal haplogroups to those made by autosomal single-nucleotide polymorphisms in 1230 samples of Affymetrix Human Origins dataset. The highest ancestry proportions of a majority of individuals match the highest average continental-ancestry proportions in haplogroups A, B, D, H, I, K, L, T, O, and M. The high consistencies have not been observed in haplogroups E, C, G, J, N, Q, and R, but in some of their sublineages, such as E1a, E1b1a1, E1b1b1b1a, E2b1a, J1a2b, Q1a1a1, Q1a2a1a1, R1b1a2a1a, and R2. Although the consistencies of Y-chromosomal and autosomal continental ancestry vary among haplogroups, Y-chromosome could provide valuable clues for individual's continental ancestry.http://www.jfsmonline.com/article.asp?issn=2349-5014;year=2016;volume=2;issue=4;spage=229;epage=232;aulast=WangAncestry inferenceautosomal single-nucleotide polymorphismY-chromosome |
| spellingShingle | Chuan-Chao Wang Lei Shang Hui-Yuan Yeh Lan-Hai Wei The Consistencies of Y-Chromosomal and Autosomal Continental Ancestry Varying among Haplogroups Journal of Forensic Science and Medicine Ancestry inference autosomal single-nucleotide polymorphism Y-chromosome |
| title | The Consistencies of Y-Chromosomal and Autosomal Continental Ancestry Varying among Haplogroups |
| title_full | The Consistencies of Y-Chromosomal and Autosomal Continental Ancestry Varying among Haplogroups |
| title_fullStr | The Consistencies of Y-Chromosomal and Autosomal Continental Ancestry Varying among Haplogroups |
| title_full_unstemmed | The Consistencies of Y-Chromosomal and Autosomal Continental Ancestry Varying among Haplogroups |
| title_short | The Consistencies of Y-Chromosomal and Autosomal Continental Ancestry Varying among Haplogroups |
| title_sort | consistencies of y chromosomal and autosomal continental ancestry varying among haplogroups |
| topic | Ancestry inference autosomal single-nucleotide polymorphism Y-chromosome |
| url | http://www.jfsmonline.com/article.asp?issn=2349-5014;year=2016;volume=2;issue=4;spage=229;epage=232;aulast=Wang |
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