Combination of LIGHT (TNFSF14)-Armed Myxoma Virus Pre-Loaded into ADSCs and Gemcitabine in the Treatment of Experimental Orthotopic Murine Pancreatic Adenocarcinoma

Combination of LIGHT (TNFSF14)-Armed Myxoma Virus Pre-Loaded into ADSCs and Gemcitabine in the Treatment of Experimental Orthotopic Murine Pancreatic Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is a deadly neoplasm. Oncolytic viruses have tumorolytic and immune response-boosting effects and present great potential for PDAC management. We used LIGHT-armed myxoma virus (vMyx-LIGHT) loaded ex vivo into human adipose-derived mesenchymal stem cells (ADSCs...

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Bibliographic Details
Main Authors: Joanna Jazowiecka-Rakus, Aleksander Sochanik, Agata Hadryś, Wojciech Fidyk, Ewa Chmielik, Masmudur M. Rahman, Grant McFadden
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cancers
Subjects:
adipose tissue-derived stem cells (ADSCs)
oncolytic virus
myxoma virus
oncolytic virotherapy
pancreatic ductal adenocarcinoma
immune response
Online Access:https://www.mdpi.com/2072-6694/14/8/2022

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