The negative prognostic impact of bone metastasis with a tumor mass

OBJECTIVE:Typically, bone metastasis causes osteolytic and osteoblastic lesions resulting from the interactions of tumor cells with osteoclasts and osteoblasts. In addition to these interactions, tumor tissues may grow inside bones and cause mass lesions. In the present study, we aimed to demonstrat...

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Main Authors: Birsen Yücel, Mustafa Gürol Celasun, Bilge Öztoprak, Zekiye Hasbek, Seher Bahar, Turgut Kaçan, Aykut Bahçeci, Mehmet Metin Şeker
Format: Article
Language:English
Published: Elsevier España 2015-08-01
Series:Clinics
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322015000800535&lng=en&tlng=en
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author Birsen Yücel
Mustafa Gürol Celasun
Bilge Öztoprak
Zekiye Hasbek
Seher Bahar
Turgut Kaçan
Aykut Bahçeci
Mehmet Metin Şeker
author_facet Birsen Yücel
Mustafa Gürol Celasun
Bilge Öztoprak
Zekiye Hasbek
Seher Bahar
Turgut Kaçan
Aykut Bahçeci
Mehmet Metin Şeker
author_sort Birsen Yücel
collection DOAJ
description OBJECTIVE:Typically, bone metastasis causes osteolytic and osteoblastic lesions resulting from the interactions of tumor cells with osteoclasts and osteoblasts. In addition to these interactions, tumor tissues may grow inside bones and cause mass lesions. In the present study, we aimed to demonstrate the negative impact of a tumor mass in a large cohort of patients with bone metastatic cancer.METHODS:Data from 335 patients with bone metastases were retrospectively reviewed. For the analysis, all patients were divided into three subgroups with respect to the type of bone metastasis: osteolytic, osteoblastic, or mixed. The patients were subsequently categorized as having bone metastasis with or without a tumor mass, and statistically significant differences in median survival and 2-year overall survival were observed between these patients (the median survival and 2-year overall survival were respectively 3 months and 16% in patients with a tumor mass and 11 months and 26% in patients without a tumor mass; p<0.001).RESULTS:According to multivariate analysis, the presence of bone metastasis with a tumor mass was found to be an independent prognostic factor (p=0.011, hazard ratio: 1.62, 95% confidence interval: 1.11–1.76). Bone metastasis with a tumor mass was more strongly associated with osteolytic lesions, other primary diseases (except for primary breast and prostate cancers), and spinal cord compression.CONCLUSION:Bone metastasis with a tumor mass is a strong and independent negative prognostic factor for survival in cancer patients.
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spelling doaj.art-56894d27086b45db87a1a04ab53886042022-12-22T00:21:22ZengElsevier EspañaClinics1980-53222015-08-0170853554010.6061/clinics/2015(08)01S1807-59322015000800535The negative prognostic impact of bone metastasis with a tumor massBirsen YücelMustafa Gürol CelasunBilge ÖztoprakZekiye HasbekSeher BaharTurgut KaçanAykut BahçeciMehmet Metin ŞekerOBJECTIVE:Typically, bone metastasis causes osteolytic and osteoblastic lesions resulting from the interactions of tumor cells with osteoclasts and osteoblasts. In addition to these interactions, tumor tissues may grow inside bones and cause mass lesions. In the present study, we aimed to demonstrate the negative impact of a tumor mass in a large cohort of patients with bone metastatic cancer.METHODS:Data from 335 patients with bone metastases were retrospectively reviewed. For the analysis, all patients were divided into three subgroups with respect to the type of bone metastasis: osteolytic, osteoblastic, or mixed. The patients were subsequently categorized as having bone metastasis with or without a tumor mass, and statistically significant differences in median survival and 2-year overall survival were observed between these patients (the median survival and 2-year overall survival were respectively 3 months and 16% in patients with a tumor mass and 11 months and 26% in patients without a tumor mass; p<0.001).RESULTS:According to multivariate analysis, the presence of bone metastasis with a tumor mass was found to be an independent prognostic factor (p=0.011, hazard ratio: 1.62, 95% confidence interval: 1.11–1.76). Bone metastasis with a tumor mass was more strongly associated with osteolytic lesions, other primary diseases (except for primary breast and prostate cancers), and spinal cord compression.CONCLUSION:Bone metastasis with a tumor mass is a strong and independent negative prognostic factor for survival in cancer patients.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322015000800535&lng=en&tlng=enBone metastasisBone metastasis with a tumor massPrognostic factorSurvival
spellingShingle Birsen Yücel
Mustafa Gürol Celasun
Bilge Öztoprak
Zekiye Hasbek
Seher Bahar
Turgut Kaçan
Aykut Bahçeci
Mehmet Metin Şeker
The negative prognostic impact of bone metastasis with a tumor mass
Clinics
Bone metastasis
Bone metastasis with a tumor mass
Prognostic factor
Survival
title The negative prognostic impact of bone metastasis with a tumor mass
title_full The negative prognostic impact of bone metastasis with a tumor mass
title_fullStr The negative prognostic impact of bone metastasis with a tumor mass
title_full_unstemmed The negative prognostic impact of bone metastasis with a tumor mass
title_short The negative prognostic impact of bone metastasis with a tumor mass
title_sort negative prognostic impact of bone metastasis with a tumor mass
topic Bone metastasis
Bone metastasis with a tumor mass
Prognostic factor
Survival
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322015000800535&lng=en&tlng=en
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