The Effect of Cardiovascular Comorbidities on Women Compared to Men: Longitudinal Retrospective Analysis
BackgroundAlthough men are more prone to developing cardiovascular disease (CVD) than women, risk factors for CVD, such as nicotine abuse and diabetes mellitus, have been shown to be more detrimental in women than in men. ObjectiveWe developed a method to systemat...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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JMIR Publications
2021-10-01
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| Series: | JMIR Cardio |
| Online Access: | https://cardio.jmir.org/2021/2/e28015 |
| _version_ | 1797735665633329152 |
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| author | Elma Dervic Carola Deischinger Nils Haug Michael Leutner Alexandra Kautzky-Willer Peter Klimek |
| author_facet | Elma Dervic Carola Deischinger Nils Haug Michael Leutner Alexandra Kautzky-Willer Peter Klimek |
| author_sort | Elma Dervic |
| collection | DOAJ |
| description |
BackgroundAlthough men are more prone to developing cardiovascular disease (CVD) than women, risk factors for CVD, such as nicotine abuse and diabetes mellitus, have been shown to be more detrimental in women than in men.
ObjectiveWe developed a method to systematically investigate population-wide electronic health records for all possible associations between risk factors for CVD and other diagnoses. The developed structured approach allows an exploratory and comprehensive screening of all possible comorbidities of CVD, which are more connected to CVD in either men or women.
MethodsBased on a population-wide medical claims dataset comprising 44 million records of inpatient stays in Austria from 2003 to 2014, we determined comorbidities of acute myocardial infarction (AMI; International Classification of Diseases, Tenth Revision [ICD-10] code I21) and chronic ischemic heart disease (CHD; ICD-10 code I25) with a significantly different prevalence in men and women. We introduced a measure of sex difference as a measure of differences in logarithmic odds ratios (ORs) between male and female patients in units of pooled standard errors.
ResultsExcept for lipid metabolism disorders (OR for females [ORf]=6.68, 95% confidence interval [CI]=6.57-6.79, OR for males [ORm]=8.31, 95% CI=8.21-8.41), all identified comorbidities were more likely to be associated with AMI and CHD in females than in males: nicotine dependence (ORf=6.16, 95% CI=5.96-6.36, ORm=4.43, 95% CI=4.35-4.5), diabetes mellitus (ORf=3.52, 95% CI=3.45-3.59, ORm=3.13, 95% CI=3.07-3.19), obesity (ORf=3.64, 95% CI=3.56-3.72, ORm=3.33, 95% CI=3.27-3.39), renal disorders (ORf=4.27, 95% CI=4.11-4.44, ORm=3.74, 95% CI=3.67-3.81), asthma (ORf=2.09, 95% CI=1.96-2.23, ORm=1.59, 95% CI=1.5-1.68), and COPD (ORf=2.09, 95% CI 1.96-2.23, ORm=1.59, 95% CI 1.5-1.68). Similar results could be observed for AMI.
ConclusionsAlthough AMI and CHD are more prevalent in men, women appear to be more affected by certain comorbidities of AMI and CHD in their risk for developing CVD. |
| first_indexed | 2024-03-12T13:02:17Z |
| format | Article |
| id | doaj.art-568987174b63487f9347468f6a205fbc |
| institution | Directory Open Access Journal |
| issn | 2561-1011 |
| language | English |
| last_indexed | 2024-03-12T13:02:17Z |
| publishDate | 2021-10-01 |
| publisher | JMIR Publications |
| record_format | Article |
| series | JMIR Cardio |
| spelling | doaj.art-568987174b63487f9347468f6a205fbc2023-08-28T19:27:45ZengJMIR PublicationsJMIR Cardio2561-10112021-10-0152e2801510.2196/28015The Effect of Cardiovascular Comorbidities on Women Compared to Men: Longitudinal Retrospective AnalysisElma Dervichttps://orcid.org/0000-0001-7168-3310Carola Deischingerhttps://orcid.org/0000-0003-4857-222XNils Haughttps://orcid.org/0000-0002-5130-9193Michael Leutnerhttps://orcid.org/0000-0003-3959-1496Alexandra Kautzky-Willerhttps://orcid.org/0000-0002-3520-4105Peter Klimekhttps://orcid.org/0000-0003-1187-6713 BackgroundAlthough men are more prone to developing cardiovascular disease (CVD) than women, risk factors for CVD, such as nicotine abuse and diabetes mellitus, have been shown to be more detrimental in women than in men. ObjectiveWe developed a method to systematically investigate population-wide electronic health records for all possible associations between risk factors for CVD and other diagnoses. The developed structured approach allows an exploratory and comprehensive screening of all possible comorbidities of CVD, which are more connected to CVD in either men or women. MethodsBased on a population-wide medical claims dataset comprising 44 million records of inpatient stays in Austria from 2003 to 2014, we determined comorbidities of acute myocardial infarction (AMI; International Classification of Diseases, Tenth Revision [ICD-10] code I21) and chronic ischemic heart disease (CHD; ICD-10 code I25) with a significantly different prevalence in men and women. We introduced a measure of sex difference as a measure of differences in logarithmic odds ratios (ORs) between male and female patients in units of pooled standard errors. ResultsExcept for lipid metabolism disorders (OR for females [ORf]=6.68, 95% confidence interval [CI]=6.57-6.79, OR for males [ORm]=8.31, 95% CI=8.21-8.41), all identified comorbidities were more likely to be associated with AMI and CHD in females than in males: nicotine dependence (ORf=6.16, 95% CI=5.96-6.36, ORm=4.43, 95% CI=4.35-4.5), diabetes mellitus (ORf=3.52, 95% CI=3.45-3.59, ORm=3.13, 95% CI=3.07-3.19), obesity (ORf=3.64, 95% CI=3.56-3.72, ORm=3.33, 95% CI=3.27-3.39), renal disorders (ORf=4.27, 95% CI=4.11-4.44, ORm=3.74, 95% CI=3.67-3.81), asthma (ORf=2.09, 95% CI=1.96-2.23, ORm=1.59, 95% CI=1.5-1.68), and COPD (ORf=2.09, 95% CI 1.96-2.23, ORm=1.59, 95% CI 1.5-1.68). Similar results could be observed for AMI. ConclusionsAlthough AMI and CHD are more prevalent in men, women appear to be more affected by certain comorbidities of AMI and CHD in their risk for developing CVD.https://cardio.jmir.org/2021/2/e28015 |
| spellingShingle | Elma Dervic Carola Deischinger Nils Haug Michael Leutner Alexandra Kautzky-Willer Peter Klimek The Effect of Cardiovascular Comorbidities on Women Compared to Men: Longitudinal Retrospective Analysis JMIR Cardio |
| title | The Effect of Cardiovascular Comorbidities on Women Compared to Men: Longitudinal Retrospective Analysis |
| title_full | The Effect of Cardiovascular Comorbidities on Women Compared to Men: Longitudinal Retrospective Analysis |
| title_fullStr | The Effect of Cardiovascular Comorbidities on Women Compared to Men: Longitudinal Retrospective Analysis |
| title_full_unstemmed | The Effect of Cardiovascular Comorbidities on Women Compared to Men: Longitudinal Retrospective Analysis |
| title_short | The Effect of Cardiovascular Comorbidities on Women Compared to Men: Longitudinal Retrospective Analysis |
| title_sort | effect of cardiovascular comorbidities on women compared to men longitudinal retrospective analysis |
| url | https://cardio.jmir.org/2021/2/e28015 |
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