Time to Publication for Randomized Clinical Trials Presented as Abstracts at Three Gastroenterology and Hepatology Conferences in 2017
Background and Aims: Results of randomized clinical trials are often first presented as conference abstracts but these abstracts may be difficult to find, and trial results included in the abstract may not be followed by subsequent journal publications. In a review of abstracts submitted to 8 major...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Gastro Hep Advances |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772572322002059 |
| _version_ | 1797843842230124544 |
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| author | Elizabeth C. Wright Devika Kapuria Gil Ben-Yakov Disha Sharma Dev Basu Min Ho Cho Tomilowo Abijo Kenneth J. Wilkins |
| author_facet | Elizabeth C. Wright Devika Kapuria Gil Ben-Yakov Disha Sharma Dev Basu Min Ho Cho Tomilowo Abijo Kenneth J. Wilkins |
| author_sort | Elizabeth C. Wright |
| collection | DOAJ |
| description | Background and Aims: Results of randomized clinical trials are often first presented as conference abstracts but these abstracts may be difficult to find, and trial results included in the abstract may not be followed by subsequent journal publications. In a review of abstracts submitted to 8 major medical and surgical conferences in 2017, we identified 237 abstracts reporting primary results of randomized clinical trials accepted for presentation at 3 major gastroenterology and hepatology conferences. The aims of this new analysis were to determine the publication rate for these abstracts and the proportion of publications that included trial registration numbers in the publication abstract. Methods: Clinical trial registries, PubMed, Europe PMC, and Google Scholar were searched through November 1, 2021 for publications reporting trial results for the selected abstracts. Publications were reviewed to determine if they included a trial registration number and if the registration number was in the abstract. Results: Publications were found for 157 abstracts (66%) within 4 years of the conference. Publications were found more frequently for the 194 abstracts reporting results of registered trials (144, 74%) than for the 43 abstracts reporting unregistered trials (13, 30%), but only 67% of these 144 publications included the registration number in the publication abstract. Ten unpublished trials had summary results posted on ClinicalTrials.gov. Conclusion: Clinical trial results could be more accessible if all trials were registered, authors included registration numbers in both conference and journal abstracts, and journal editors required the inclusion of registration numbers in publication abstracts for registered clinical trials. |
| first_indexed | 2024-04-09T17:12:34Z |
| format | Article |
| id | doaj.art-56899cb8cf4c4d258a440b02fd42f1d2 |
| institution | Directory Open Access Journal |
| issn | 2772-5723 |
| language | English |
| last_indexed | 2024-04-09T17:12:34Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gastro Hep Advances |
| spelling | doaj.art-56899cb8cf4c4d258a440b02fd42f1d22023-04-20T04:37:58ZengElsevierGastro Hep Advances2772-57232023-01-0123370379Time to Publication for Randomized Clinical Trials Presented as Abstracts at Three Gastroenterology and Hepatology Conferences in 2017Elizabeth C. Wright0Devika Kapuria1Gil Ben-Yakov2Disha Sharma3Dev Basu4Min Ho Cho5Tomilowo Abijo6Kenneth J. Wilkins7Office of the Director, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland; Correspondence: Address correspondence to: Elizabeth C. Wright, PhD, NIDDK/NIH, 6707 Democracy Blvd., Room 7101, Bethesda, Maryland 20892.Department of Gastroenterology, Washington University in St. Louis, St. Louis, MissouriThe Center for liver diseases Sheba, Tel-Hashomer medical center, Ramat Gan, IsraelLiver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MarylandMedstar Good Samaritan Hospital, Baltimore, MarylandDepartment of Medicine, Baystate Medical Center, Springfield, MassachusettsOffice of the Director, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MarylandOffice of the Director, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MarylandBackground and Aims: Results of randomized clinical trials are often first presented as conference abstracts but these abstracts may be difficult to find, and trial results included in the abstract may not be followed by subsequent journal publications. In a review of abstracts submitted to 8 major medical and surgical conferences in 2017, we identified 237 abstracts reporting primary results of randomized clinical trials accepted for presentation at 3 major gastroenterology and hepatology conferences. The aims of this new analysis were to determine the publication rate for these abstracts and the proportion of publications that included trial registration numbers in the publication abstract. Methods: Clinical trial registries, PubMed, Europe PMC, and Google Scholar were searched through November 1, 2021 for publications reporting trial results for the selected abstracts. Publications were reviewed to determine if they included a trial registration number and if the registration number was in the abstract. Results: Publications were found for 157 abstracts (66%) within 4 years of the conference. Publications were found more frequently for the 194 abstracts reporting results of registered trials (144, 74%) than for the 43 abstracts reporting unregistered trials (13, 30%), but only 67% of these 144 publications included the registration number in the publication abstract. Ten unpublished trials had summary results posted on ClinicalTrials.gov. Conclusion: Clinical trial results could be more accessible if all trials were registered, authors included registration numbers in both conference and journal abstracts, and journal editors required the inclusion of registration numbers in publication abstracts for registered clinical trials.http://www.sciencedirect.com/science/article/pii/S2772572322002059CONSORTPublication biasTrial registrationConference |
| spellingShingle | Elizabeth C. Wright Devika Kapuria Gil Ben-Yakov Disha Sharma Dev Basu Min Ho Cho Tomilowo Abijo Kenneth J. Wilkins Time to Publication for Randomized Clinical Trials Presented as Abstracts at Three Gastroenterology and Hepatology Conferences in 2017 Gastro Hep Advances CONSORT Publication bias Trial registration Conference |
| title | Time to Publication for Randomized Clinical Trials Presented as Abstracts at Three Gastroenterology and Hepatology Conferences in 2017 |
| title_full | Time to Publication for Randomized Clinical Trials Presented as Abstracts at Three Gastroenterology and Hepatology Conferences in 2017 |
| title_fullStr | Time to Publication for Randomized Clinical Trials Presented as Abstracts at Three Gastroenterology and Hepatology Conferences in 2017 |
| title_full_unstemmed | Time to Publication for Randomized Clinical Trials Presented as Abstracts at Three Gastroenterology and Hepatology Conferences in 2017 |
| title_short | Time to Publication for Randomized Clinical Trials Presented as Abstracts at Three Gastroenterology and Hepatology Conferences in 2017 |
| title_sort | time to publication for randomized clinical trials presented as abstracts at three gastroenterology and hepatology conferences in 2017 |
| topic | CONSORT Publication bias Trial registration Conference |
| url | http://www.sciencedirect.com/science/article/pii/S2772572322002059 |
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