Protective Effects of Green Tea Supplementation against Lead-Induced Neurotoxicity in Mice
The use of natural products as therapeutic agents is rapidly growing recently. In the current study, we investigated the protective effects of green tea supplementation on lead-induced toxicity in mice. Forty albino mice were divided into four groups as follows: A: control group; B: green tea receiv...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-02-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/27/3/993 |
| _version_ | 1797486025722822656 |
|---|---|
| author | Areej Al-Qahtani Jamaan Ajarem Mohammad K. Okla Samina Rubnawaz Saud A. Alamri Wahidah H. Al-Qahtani Ahmad R. Al-Himaidi Hamada Abd Elgawad Nosheen Akhtar Saleh N. Maodaa Mostafa A. Abdel-Maksoud |
| author_facet | Areej Al-Qahtani Jamaan Ajarem Mohammad K. Okla Samina Rubnawaz Saud A. Alamri Wahidah H. Al-Qahtani Ahmad R. Al-Himaidi Hamada Abd Elgawad Nosheen Akhtar Saleh N. Maodaa Mostafa A. Abdel-Maksoud |
| author_sort | Areej Al-Qahtani |
| collection | DOAJ |
| description | The use of natural products as therapeutic agents is rapidly growing recently. In the current study, we investigated the protective effects of green tea supplementation on lead-induced toxicity in mice. Forty albino mice were divided into four groups as follows: A: control group; B: green tea receiving group; C: lead-intoxicated group; and D: lead-intoxicated group supplemented with green tea. At the end of the experiment, the animals were tested for neurobehavioral and biochemical alterations. Green tea was analyzed through Gas Chromatography–Mass Spectrometry (GC/MS) analysis. We found that supplementation with green tea ameliorated the lead-associated increase in body weight and blood glucose. Green tea supplementation also changed the blood picture that was affected due to lead toxicity and ameliorated lead-induced dyslipidemia. The group of mice that were supplemented with green tea has shown positive alterations in locomotory, anxiety, memory, and learning behaviors. The GC/MS analysis revealed many active ingredients among which the two most abundant were caffeine and 1,2-benzenedicarboxylic acid, mono(2-ethylhexyl) ester. We concluded that green tea supplementation has several positive effects on the lead-induced neurotoxicity in mice and that these effects may be attributed to its main two active ingredients. |
| first_indexed | 2024-03-09T23:27:17Z |
| format | Article |
| id | doaj.art-568a5ebbcf464af8a64d61f725023288 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T23:27:17Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-568a5ebbcf464af8a64d61f7250232882023-11-23T17:15:53ZengMDPI AGMolecules1420-30492022-02-0127399310.3390/molecules27030993Protective Effects of Green Tea Supplementation against Lead-Induced Neurotoxicity in MiceAreej Al-Qahtani0Jamaan Ajarem1Mohammad K. Okla2Samina Rubnawaz3Saud A. Alamri4Wahidah H. Al-Qahtani5Ahmad R. Al-Himaidi6Hamada Abd Elgawad7Nosheen Akhtar8Saleh N. Maodaa9Mostafa A. Abdel-Maksoud10Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Biochemistry, Faculty of Biological Sciences, Quaid I Azam University, Islamabad 45320, PakistanDepartment of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Food Sciences & Nutrition, College of Food & Agriculture Sciences, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaIntegrated Molecular Plant Physiology Research, Department of Biology, University of Antwerp, 2020 Antwerpen, BelgiumDepartment of Biological Sciences, National University of Medical Sciences, Rawalpindi 46000, PakistanDepartment of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaThe use of natural products as therapeutic agents is rapidly growing recently. In the current study, we investigated the protective effects of green tea supplementation on lead-induced toxicity in mice. Forty albino mice were divided into four groups as follows: A: control group; B: green tea receiving group; C: lead-intoxicated group; and D: lead-intoxicated group supplemented with green tea. At the end of the experiment, the animals were tested for neurobehavioral and biochemical alterations. Green tea was analyzed through Gas Chromatography–Mass Spectrometry (GC/MS) analysis. We found that supplementation with green tea ameliorated the lead-associated increase in body weight and blood glucose. Green tea supplementation also changed the blood picture that was affected due to lead toxicity and ameliorated lead-induced dyslipidemia. The group of mice that were supplemented with green tea has shown positive alterations in locomotory, anxiety, memory, and learning behaviors. The GC/MS analysis revealed many active ingredients among which the two most abundant were caffeine and 1,2-benzenedicarboxylic acid, mono(2-ethylhexyl) ester. We concluded that green tea supplementation has several positive effects on the lead-induced neurotoxicity in mice and that these effects may be attributed to its main two active ingredients.https://www.mdpi.com/1420-3049/27/3/993caffeinedyslipidemiaGC/MSlead toxicityneurobehavior |
| spellingShingle | Areej Al-Qahtani Jamaan Ajarem Mohammad K. Okla Samina Rubnawaz Saud A. Alamri Wahidah H. Al-Qahtani Ahmad R. Al-Himaidi Hamada Abd Elgawad Nosheen Akhtar Saleh N. Maodaa Mostafa A. Abdel-Maksoud Protective Effects of Green Tea Supplementation against Lead-Induced Neurotoxicity in Mice Molecules caffeine dyslipidemia GC/MS lead toxicity neurobehavior |
| title | Protective Effects of Green Tea Supplementation against Lead-Induced Neurotoxicity in Mice |
| title_full | Protective Effects of Green Tea Supplementation against Lead-Induced Neurotoxicity in Mice |
| title_fullStr | Protective Effects of Green Tea Supplementation against Lead-Induced Neurotoxicity in Mice |
| title_full_unstemmed | Protective Effects of Green Tea Supplementation against Lead-Induced Neurotoxicity in Mice |
| title_short | Protective Effects of Green Tea Supplementation against Lead-Induced Neurotoxicity in Mice |
| title_sort | protective effects of green tea supplementation against lead induced neurotoxicity in mice |
| topic | caffeine dyslipidemia GC/MS lead toxicity neurobehavior |
| url | https://www.mdpi.com/1420-3049/27/3/993 |
| work_keys_str_mv | AT areejalqahtani protectiveeffectsofgreenteasupplementationagainstleadinducedneurotoxicityinmice AT jamaanajarem protectiveeffectsofgreenteasupplementationagainstleadinducedneurotoxicityinmice AT mohammadkokla protectiveeffectsofgreenteasupplementationagainstleadinducedneurotoxicityinmice AT saminarubnawaz protectiveeffectsofgreenteasupplementationagainstleadinducedneurotoxicityinmice AT saudaalamri protectiveeffectsofgreenteasupplementationagainstleadinducedneurotoxicityinmice AT wahidahhalqahtani protectiveeffectsofgreenteasupplementationagainstleadinducedneurotoxicityinmice AT ahmadralhimaidi protectiveeffectsofgreenteasupplementationagainstleadinducedneurotoxicityinmice AT hamadaabdelgawad protectiveeffectsofgreenteasupplementationagainstleadinducedneurotoxicityinmice AT nosheenakhtar protectiveeffectsofgreenteasupplementationagainstleadinducedneurotoxicityinmice AT salehnmaodaa protectiveeffectsofgreenteasupplementationagainstleadinducedneurotoxicityinmice AT mostafaaabdelmaksoud protectiveeffectsofgreenteasupplementationagainstleadinducedneurotoxicityinmice |