Differential protein profiling in brain and spinal arteriovenous malformations
Objective To explore the differences of protein profiling between brain arteriovenous malformation (bAVM) and spinal AVM (sAVM). Methods Proteins were extracted from bAVM,sAVM,control cerebrovascular and control spinal vessel specimens. The protein level in each group was measured by TMT-labe...
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| Format: | Article |
| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2021-11-01
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| Series: | Jichu yixue yu linchuang |
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| Online Access: | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a210414.pdf |
| _version_ | 1797365715443908608 |
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| author | WANG Nai-li, MENG Shu, QIU Wen-ying, WANG Xia |
| author_facet | WANG Nai-li, MENG Shu, QIU Wen-ying, WANG Xia |
| author_sort | WANG Nai-li, MENG Shu, QIU Wen-ying, WANG Xia |
| collection | DOAJ |
| description | Objective To explore the differences of protein profiling between brain arteriovenous malformation (bAVM) and spinal AVM (sAVM). Methods Proteins were extracted from bAVM,sAVM,control cerebrovascular and control spinal vessel specimens. The protein level in each group was measured by TMT-labeled quantitative proteomics. Results Totally 3 102 protein samples from bAVM, sAVM,control cerebrovascular and control spinal vessel were examined by high-throughput quantitative proteomics. Among them the expression level of 852 proteins was dramatically changed in bAVM and 205 proteins in sAVM. Bioinformatic analysis showed that 304 proteins were highly expressed only in bAVM, most of them were mitochondria proteins, mainly enriched in electron transport chain and calcium regulation pathways, 97 proteins were specifically highly expressed in sAVM associated with extracellular matrix organization. Conclusions The mitochondrial dysfunction and calcium regulation imbalance may play important roles in the process of bAVM. Disturbed extracellular matrix organization and glycoproteins are potentially involved in sAVM progression. |
| first_indexed | 2024-03-08T16:53:52Z |
| format | Article |
| id | doaj.art-568b7fc119a94d0e8723474fc1b6c016 |
| institution | Directory Open Access Journal |
| issn | 1001-6325 |
| language | zho |
| last_indexed | 2024-03-08T16:53:52Z |
| publishDate | 2021-11-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj.art-568b7fc119a94d0e8723474fc1b6c0162024-01-05T03:07:24ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252021-11-01411115701576Differential protein profiling in brain and spinal arteriovenous malformationsWANG Nai-li, MENG Shu, QIU Wen-ying, WANG Xia01. Department of Human Anatomy,Histology and Embryology; 2. Department of Immunology,Institute of Basic Medical Sciences CAMS, School of Basic Medicine PUMC, Beijing 100005,ChinaObjective To explore the differences of protein profiling between brain arteriovenous malformation (bAVM) and spinal AVM (sAVM). Methods Proteins were extracted from bAVM,sAVM,control cerebrovascular and control spinal vessel specimens. The protein level in each group was measured by TMT-labeled quantitative proteomics. Results Totally 3 102 protein samples from bAVM, sAVM,control cerebrovascular and control spinal vessel were examined by high-throughput quantitative proteomics. Among them the expression level of 852 proteins was dramatically changed in bAVM and 205 proteins in sAVM. Bioinformatic analysis showed that 304 proteins were highly expressed only in bAVM, most of them were mitochondria proteins, mainly enriched in electron transport chain and calcium regulation pathways, 97 proteins were specifically highly expressed in sAVM associated with extracellular matrix organization. Conclusions The mitochondrial dysfunction and calcium regulation imbalance may play important roles in the process of bAVM. Disturbed extracellular matrix organization and glycoproteins are potentially involved in sAVM progression.http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a210414.pdfbrain arteriovenous malformation|spinal arteriovenous malformation|proteomics|mitochondria|extracellular matrix |
| spellingShingle | WANG Nai-li, MENG Shu, QIU Wen-ying, WANG Xia Differential protein profiling in brain and spinal arteriovenous malformations Jichu yixue yu linchuang brain arteriovenous malformation|spinal arteriovenous malformation|proteomics|mitochondria|extracellular matrix |
| title | Differential protein profiling in brain and spinal arteriovenous malformations |
| title_full | Differential protein profiling in brain and spinal arteriovenous malformations |
| title_fullStr | Differential protein profiling in brain and spinal arteriovenous malformations |
| title_full_unstemmed | Differential protein profiling in brain and spinal arteriovenous malformations |
| title_short | Differential protein profiling in brain and spinal arteriovenous malformations |
| title_sort | differential protein profiling in brain and spinal arteriovenous malformations |
| topic | brain arteriovenous malformation|spinal arteriovenous malformation|proteomics|mitochondria|extracellular matrix |
| url | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a210414.pdf |
| work_keys_str_mv | AT wangnailimengshuqiuwenyingwangxia differentialproteinprofilinginbrainandspinalarteriovenousmalformations |