Developmental Cues and Molecular Drivers in Myelinogenesis: Revisiting Early Life to Re-Evaluate the Integrity of CNS Myelin
The mammalian central nervous system (CNS) coordinates its communication through saltatory conduction, facilitated by myelin-forming oligodendrocytes (OLs). Despite the fact that neurogenesis from stem cell niches has caught the majority of attention in recent years, oligodendrogenesis and, more spe...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/44/7/222 |
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| author | Iasonas Dermitzakis Maria Eleni Manthou Soultana Meditskou Dimosthenis Miliaras Evangelia Kesidou Marina Boziki Steven Petratos Nikolaos Grigoriadis Paschalis Theotokis |
| author_facet | Iasonas Dermitzakis Maria Eleni Manthou Soultana Meditskou Dimosthenis Miliaras Evangelia Kesidou Marina Boziki Steven Petratos Nikolaos Grigoriadis Paschalis Theotokis |
| author_sort | Iasonas Dermitzakis |
| collection | DOAJ |
| description | The mammalian central nervous system (CNS) coordinates its communication through saltatory conduction, facilitated by myelin-forming oligodendrocytes (OLs). Despite the fact that neurogenesis from stem cell niches has caught the majority of attention in recent years, oligodendrogenesis and, more specifically, the molecular underpinnings behind OL-dependent myelinogenesis, remain largely unknown. In this comprehensive review, we determine the developmental cues and molecular drivers which regulate normal myelination both at the prenatal and postnatal periods. We have indexed the individual stages of myelinogenesis sequentially; from the initiation of oligodendrocyte precursor cells, including migration and proliferation, to first contact with the axon that enlists positive and negative regulators for myelination, until the ultimate maintenance of the axon ensheathment and myelin growth. Here, we highlight multiple developmental pathways that are key to successful myelin formation and define the molecular pathways that can potentially be targets for pharmacological interventions in a variety of neurological disorders that exhibit demyelination. |
| first_indexed | 2024-03-09T12:04:39Z |
| format | Article |
| id | doaj.art-568bb1dc5bda4ac09999993b13f4473f |
| institution | Directory Open Access Journal |
| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-09T12:04:39Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj.art-568bb1dc5bda4ac09999993b13f4473f2023-11-30T22:59:33ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452022-07-014473208323710.3390/cimb44070222Developmental Cues and Molecular Drivers in Myelinogenesis: Revisiting Early Life to Re-Evaluate the Integrity of CNS MyelinIasonas Dermitzakis0Maria Eleni Manthou1Soultana Meditskou2Dimosthenis Miliaras3Evangelia Kesidou4Marina Boziki5Steven Petratos6Nikolaos Grigoriadis7Paschalis Theotokis8Department of Histology-Embryology, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceDepartment of Histology-Embryology, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceDepartment of Histology-Embryology, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceDepartment of Histology-Embryology, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceLaboratory of Experimental Neurology and Neuroimmunology, Second Department of Neurology, AHEPA University Hospital, 54621 Thessaloniki, GreeceLaboratory of Experimental Neurology and Neuroimmunology, Second Department of Neurology, AHEPA University Hospital, 54621 Thessaloniki, GreeceDepartment of Neuroscience, Central Clinical School, Monash University, Prahran, VIC 3004, AustraliaLaboratory of Experimental Neurology and Neuroimmunology, Second Department of Neurology, AHEPA University Hospital, 54621 Thessaloniki, GreeceDepartment of Histology-Embryology, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceThe mammalian central nervous system (CNS) coordinates its communication through saltatory conduction, facilitated by myelin-forming oligodendrocytes (OLs). Despite the fact that neurogenesis from stem cell niches has caught the majority of attention in recent years, oligodendrogenesis and, more specifically, the molecular underpinnings behind OL-dependent myelinogenesis, remain largely unknown. In this comprehensive review, we determine the developmental cues and molecular drivers which regulate normal myelination both at the prenatal and postnatal periods. We have indexed the individual stages of myelinogenesis sequentially; from the initiation of oligodendrocyte precursor cells, including migration and proliferation, to first contact with the axon that enlists positive and negative regulators for myelination, until the ultimate maintenance of the axon ensheathment and myelin growth. Here, we highlight multiple developmental pathways that are key to successful myelin formation and define the molecular pathways that can potentially be targets for pharmacological interventions in a variety of neurological disorders that exhibit demyelination.https://www.mdpi.com/1467-3045/44/7/222oligodendrogenesismyelinogenesismyelin formationembryologyCNS developmentneural tube development |
| spellingShingle | Iasonas Dermitzakis Maria Eleni Manthou Soultana Meditskou Dimosthenis Miliaras Evangelia Kesidou Marina Boziki Steven Petratos Nikolaos Grigoriadis Paschalis Theotokis Developmental Cues and Molecular Drivers in Myelinogenesis: Revisiting Early Life to Re-Evaluate the Integrity of CNS Myelin Current Issues in Molecular Biology oligodendrogenesis myelinogenesis myelin formation embryology CNS development neural tube development |
| title | Developmental Cues and Molecular Drivers in Myelinogenesis: Revisiting Early Life to Re-Evaluate the Integrity of CNS Myelin |
| title_full | Developmental Cues and Molecular Drivers in Myelinogenesis: Revisiting Early Life to Re-Evaluate the Integrity of CNS Myelin |
| title_fullStr | Developmental Cues and Molecular Drivers in Myelinogenesis: Revisiting Early Life to Re-Evaluate the Integrity of CNS Myelin |
| title_full_unstemmed | Developmental Cues and Molecular Drivers in Myelinogenesis: Revisiting Early Life to Re-Evaluate the Integrity of CNS Myelin |
| title_short | Developmental Cues and Molecular Drivers in Myelinogenesis: Revisiting Early Life to Re-Evaluate the Integrity of CNS Myelin |
| title_sort | developmental cues and molecular drivers in myelinogenesis revisiting early life to re evaluate the integrity of cns myelin |
| topic | oligodendrogenesis myelinogenesis myelin formation embryology CNS development neural tube development |
| url | https://www.mdpi.com/1467-3045/44/7/222 |
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