Attenuation of mouse hepatitis virus by deletion of the LLRKxGxKG region of Nsp1.

Attenuation of mouse hepatitis virus by deletion of the LLRKxGxKG region of Nsp1.

Coronaviruses are a family of large positive-sense RNA viruses that are responsible for a wide range of important veterinary and human diseases. Nsp1 has been shown to have an important role in the pathogenetic mechanisms of coronaviruses in vivo. To assess the function of a relatively conserved dom...

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Bibliographic Details
Main Authors: Lin Lei, Sun Ying, Luo Baojun, Yang Yi, He Xiang, Su Wenli, Sun Zounan, Guo Deyin, Zhu Qingyu, Liu Jingmei, Chang Guohui
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23593419/pdf/?tool=EBI

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