Bioelectromagnetic Platform for Cell, Tissue, and In Vivo Stimulation

Magnetogenetics is a new field that utilizes electromagnetic fields to remotely control cellular activity. In addition to the development of the biological genetic tools, this approach requires designing hardware with a specific set of demands for the electromagnets used to provide the desired stimu...

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Bibliographic Details
Main Authors: Ryan C. Ashbaugh, Lalita Udpa, Ron R. Israeli, Assaf A. Gilad, Galit Pelled
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Biosensors
Subjects:
Online Access:https://www.mdpi.com/2079-6374/11/8/248
Description
Summary:Magnetogenetics is a new field that utilizes electromagnetic fields to remotely control cellular activity. In addition to the development of the biological genetic tools, this approach requires designing hardware with a specific set of demands for the electromagnets used to provide the desired stimulation for electrophysiology and imaging experiments. Here, we present a universal stimulus delivery system comprising four magnet designs compatible with electrophysiology, fluorescence and luminescence imaging, microscopy, and freely behaving animal experiments. The overall system includes a low-cost stimulation controller that enables rapid switching between active and sham stimulation trials as well as precise control of stimulation delivery thereby enabling repeatable and reproducible measurements.
ISSN:2079-6374