Bioelectromagnetic Platform for Cell, Tissue, and In Vivo Stimulation
Magnetogenetics is a new field that utilizes electromagnetic fields to remotely control cellular activity. In addition to the development of the biological genetic tools, this approach requires designing hardware with a specific set of demands for the electromagnets used to provide the desired stimu...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Biosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6374/11/8/248 |
| _version_ | 1797524505543835648 |
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| author | Ryan C. Ashbaugh Lalita Udpa Ron R. Israeli Assaf A. Gilad Galit Pelled |
| author_facet | Ryan C. Ashbaugh Lalita Udpa Ron R. Israeli Assaf A. Gilad Galit Pelled |
| author_sort | Ryan C. Ashbaugh |
| collection | DOAJ |
| description | Magnetogenetics is a new field that utilizes electromagnetic fields to remotely control cellular activity. In addition to the development of the biological genetic tools, this approach requires designing hardware with a specific set of demands for the electromagnets used to provide the desired stimulation for electrophysiology and imaging experiments. Here, we present a universal stimulus delivery system comprising four magnet designs compatible with electrophysiology, fluorescence and luminescence imaging, microscopy, and freely behaving animal experiments. The overall system includes a low-cost stimulation controller that enables rapid switching between active and sham stimulation trials as well as precise control of stimulation delivery thereby enabling repeatable and reproducible measurements. |
| first_indexed | 2024-03-10T08:58:22Z |
| format | Article |
| id | doaj.art-568cd36556d846cabd75b852a6485eee |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-10T08:58:22Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-568cd36556d846cabd75b852a6485eee2023-11-22T06:57:19ZengMDPI AGBiosensors2079-63742021-07-0111824810.3390/bios11080248Bioelectromagnetic Platform for Cell, Tissue, and In Vivo StimulationRyan C. Ashbaugh0Lalita Udpa1Ron R. Israeli2Assaf A. Gilad3Galit Pelled4Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI 48824, USADepartment of Electrical and Computer Engineering, Michigan State University, East Lansing, MI 48824, USANeuroengineering Division, Michigan State University, East Lansing, MI 48824, USADepartment of Biomedical Engineering, Michigan State University, East Lansing, MI 48824, USANeuroengineering Division, Michigan State University, East Lansing, MI 48824, USAMagnetogenetics is a new field that utilizes electromagnetic fields to remotely control cellular activity. In addition to the development of the biological genetic tools, this approach requires designing hardware with a specific set of demands for the electromagnets used to provide the desired stimulation for electrophysiology and imaging experiments. Here, we present a universal stimulus delivery system comprising four magnet designs compatible with electrophysiology, fluorescence and luminescence imaging, microscopy, and freely behaving animal experiments. The overall system includes a low-cost stimulation controller that enables rapid switching between active and sham stimulation trials as well as precise control of stimulation delivery thereby enabling repeatable and reproducible measurements.https://www.mdpi.com/2079-6374/11/8/248high-throughput magnetogeneticsin vivo stimulationhead-fixed experimentsneuromodulationminimally-invasive brain stimulation |
| spellingShingle | Ryan C. Ashbaugh Lalita Udpa Ron R. Israeli Assaf A. Gilad Galit Pelled Bioelectromagnetic Platform for Cell, Tissue, and In Vivo Stimulation Biosensors high-throughput magnetogenetics in vivo stimulation head-fixed experiments neuromodulation minimally-invasive brain stimulation |
| title | Bioelectromagnetic Platform for Cell, Tissue, and In Vivo Stimulation |
| title_full | Bioelectromagnetic Platform for Cell, Tissue, and In Vivo Stimulation |
| title_fullStr | Bioelectromagnetic Platform for Cell, Tissue, and In Vivo Stimulation |
| title_full_unstemmed | Bioelectromagnetic Platform for Cell, Tissue, and In Vivo Stimulation |
| title_short | Bioelectromagnetic Platform for Cell, Tissue, and In Vivo Stimulation |
| title_sort | bioelectromagnetic platform for cell tissue and in vivo stimulation |
| topic | high-throughput magnetogenetics in vivo stimulation head-fixed experiments neuromodulation minimally-invasive brain stimulation |
| url | https://www.mdpi.com/2079-6374/11/8/248 |
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