Histoplasmosis: An epidemiological and clinical update in China, review and a case report
ABSTRACTHistoplasmosis is a systemic mycosis caused by the dimorphic fungus in the genus Histoplasma. Histoplasmosis is overlooked in China. This study aims to provide an epidemiological and clinical update on histoplasmosis in China by literature review. We reviewed cases of histoplasmosis reported...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-01-01
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| Series: | Mycology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/21501203.2023.2259934 |
| _version_ | 1797242543786688512 |
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| author | Lihua Chen Danyang Hu Congming Zhang Tianrui Wu Xiangning Cheng Ferry Hagen Hui Zhu Shuwen Deng |
| author_facet | Lihua Chen Danyang Hu Congming Zhang Tianrui Wu Xiangning Cheng Ferry Hagen Hui Zhu Shuwen Deng |
| author_sort | Lihua Chen |
| collection | DOAJ |
| description | ABSTRACTHistoplasmosis is a systemic mycosis caused by the dimorphic fungus in the genus Histoplasma. Histoplasmosis is overlooked in China. This study aims to provide an epidemiological and clinical update on histoplasmosis in China by literature review. We reviewed cases of histoplasmosis reported in recent 11 years and described a case of histoplasmosis-triggered hemophagocytic lymphohistiocytosis (HLH) in an immunocompetent patient. A total of 225 cases of histoplasmosis diagnosed in China between 2012 and 2022 were involved in this study, compared with 300 cases reviewed from 1990 to 2011, an increasing number of cases of histoplasmosis have been diagnosed in the last 11 years. The majority of cases of histoplasmosis were autochthonous cases, mainly from provinces Sichuan (56/225, 24.9%), Hunan (50/225, 22.2%), Guangdong (31/225, 13.8%), and Yunnan (24/225, 10.7%). Higher incidence (52.5%, 53/99) of histoplasmosis occurred in immunocompetent patients which is similar to those from the previous 21 years, and the prevalence of the disease did not vary highly over time. Of note, the number of histoplasmosis cases is increasing, and the geographic distribution is shifting southwards over time. Improved awareness is critically important for informing clinical practice in China. |
| first_indexed | 2024-04-24T18:40:54Z |
| format | Article |
| id | doaj.art-568d2dafb8f54ca8b8d1d13f8b0a086d |
| institution | Directory Open Access Journal |
| issn | 2150-1203 2150-1211 |
| language | English |
| last_indexed | 2024-04-24T18:40:54Z |
| publishDate | 2024-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Mycology |
| spelling | doaj.art-568d2dafb8f54ca8b8d1d13f8b0a086d2024-03-27T12:44:52ZengTaylor & Francis GroupMycology2150-12032150-12112024-01-0115110110910.1080/21501203.2023.2259934Histoplasmosis: An epidemiological and clinical update in China, review and a case reportLihua Chen0Danyang Hu1Congming Zhang2Tianrui Wu3Xiangning Cheng4Ferry Hagen5Hui Zhu6Shuwen Deng7Department of Medicine Laboratory, The Third Xiangya Hospital of Central South University, Changsha, ChinaLife Science College, University of Essex, Colchester, UKDepartment of hematology, The Third Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Medicine Laboratory, The Third Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Medicine Laboratory, The Third Xiangya Hospital of Central South University, Changsha, ChinaWesterdijk Fungal Biodiversity Institute, Utrecht, The NetherlandsDepartment of Gynaecology and Obstetrics, The First Hospital of Suzhou University, Suzhou, ChinaMedical Center in The People’s Hospital of SND, Suzhou, ChinaABSTRACTHistoplasmosis is a systemic mycosis caused by the dimorphic fungus in the genus Histoplasma. Histoplasmosis is overlooked in China. This study aims to provide an epidemiological and clinical update on histoplasmosis in China by literature review. We reviewed cases of histoplasmosis reported in recent 11 years and described a case of histoplasmosis-triggered hemophagocytic lymphohistiocytosis (HLH) in an immunocompetent patient. A total of 225 cases of histoplasmosis diagnosed in China between 2012 and 2022 were involved in this study, compared with 300 cases reviewed from 1990 to 2011, an increasing number of cases of histoplasmosis have been diagnosed in the last 11 years. The majority of cases of histoplasmosis were autochthonous cases, mainly from provinces Sichuan (56/225, 24.9%), Hunan (50/225, 22.2%), Guangdong (31/225, 13.8%), and Yunnan (24/225, 10.7%). Higher incidence (52.5%, 53/99) of histoplasmosis occurred in immunocompetent patients which is similar to those from the previous 21 years, and the prevalence of the disease did not vary highly over time. Of note, the number of histoplasmosis cases is increasing, and the geographic distribution is shifting southwards over time. Improved awareness is critically important for informing clinical practice in China.https://www.tandfonline.com/doi/10.1080/21501203.2023.2259934HistoplasmosisHistoplasma capsulatumepidemiologyhemophagocytic lymphohistiocytosisChina |
| spellingShingle | Lihua Chen Danyang Hu Congming Zhang Tianrui Wu Xiangning Cheng Ferry Hagen Hui Zhu Shuwen Deng Histoplasmosis: An epidemiological and clinical update in China, review and a case report Mycology Histoplasmosis Histoplasma capsulatum epidemiology hemophagocytic lymphohistiocytosis China |
| title | Histoplasmosis: An epidemiological and clinical update in China, review and a case report |
| title_full | Histoplasmosis: An epidemiological and clinical update in China, review and a case report |
| title_fullStr | Histoplasmosis: An epidemiological and clinical update in China, review and a case report |
| title_full_unstemmed | Histoplasmosis: An epidemiological and clinical update in China, review and a case report |
| title_short | Histoplasmosis: An epidemiological and clinical update in China, review and a case report |
| title_sort | histoplasmosis an epidemiological and clinical update in china review and a case report |
| topic | Histoplasmosis Histoplasma capsulatum epidemiology hemophagocytic lymphohistiocytosis China |
| url | https://www.tandfonline.com/doi/10.1080/21501203.2023.2259934 |
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