The relationship between neonatal factors and involving with glucose-6-phosphate dehydrogenase deficiency (G6PD) and patients\' outcome in Fars Province
Introduction: Glucose-6-phosphate dehydrogenase deficiency (G6PD) or fauvism is the most common enzyme deficiency in human, so that 400 million people are living with this disease worldwide. This study aimed to investigate the role of some neonatal factors among newborns suffering from G6PD deficien...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Ilam University of Medical Sciences
2018-01-01
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| Series: | Journal of Basic Research in Medical Sciences |
| Subjects: | |
| Online Access: | http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-272-1&slc_lang=en&sid=1 |
| _version_ | 1819176636157788160 |
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| author | Salman Daliri Khairollah Asadollahi Mir Hadi Musavi Arezou Karimi Gholam Ali Khademi Monire Azizi Ghobad Abangah |
| author_facet | Salman Daliri Khairollah Asadollahi Mir Hadi Musavi Arezou Karimi Gholam Ali Khademi Monire Azizi Ghobad Abangah |
| author_sort | Salman Daliri |
| collection | DOAJ |
| description | Introduction: Glucose-6-phosphate dehydrogenase deficiency (G6PD) or fauvism is the most common enzyme deficiency in human, so that 400 million people are living with this disease worldwide. This study aimed to investigate the role of some neonatal factors among newborns suffering from G6PD deficiency and neonatal outcomes associated with this disease.
Materials and methods: In this study, two methods including case-control and retrospective cohort regarding some neonatal factors associated with G6PD deficiency were used. These methods were performed on 142 children with this kind of deficiency and 142 healthy infants in the city of Marvdasht during 2013- 2014. The analysis of data was based on chi-square tests, t-test, logistic regression, descriptive statistics and estimation of odds ratios or relative risks via SPSS16 software.
Results: Totally 284 newborns including 132 (46.6%)/ 152 (53.4%) boys/girls and mean weight on birth of 3163 ± 471 (gr) were analyzed. Comparison of case and control samples did not show any significant differences between sex and involving with G6PD deficiency but the chance of having a baby with this defect in pregnancy intervals between 6 to 8 years was increased (95% CI: 1- 4.4, OR: 2). Relative risk of jaundice in infected and healthy infants was estimated as 3.73, which demonstrated a statistically significant association (95% CI: 1.33- 10.4). The frequency of low birth weight, birth order and type of delivery was associated with the disease, but their differences were insignificant compared to the healthy group.
Conclusion: The results of this study showed that the number of hospitalization is increased due to jaundice in infants with G6PD. There is also an insignificant relation between low birth weight, rank of birth and type of delivery. Thus, it is recommended that other consequences of this deficiency need to be revealed by screening other populations with more samples. |
| first_indexed | 2024-12-22T21:13:54Z |
| format | Article |
| id | doaj.art-568ea1fc304040848534df6c3a9b19d8 |
| institution | Directory Open Access Journal |
| issn | 2383-0506 2383-0972 |
| language | English |
| last_indexed | 2024-12-22T21:13:54Z |
| publishDate | 2018-01-01 |
| publisher | Ilam University of Medical Sciences |
| record_format | Article |
| series | Journal of Basic Research in Medical Sciences |
| spelling | doaj.art-568ea1fc304040848534df6c3a9b19d82022-12-21T18:12:25ZengIlam University of Medical SciencesJournal of Basic Research in Medical Sciences2383-05062383-09722018-01-01511521The relationship between neonatal factors and involving with glucose-6-phosphate dehydrogenase deficiency (G6PD) and patients\' outcome in Fars ProvinceSalman Daliri0Khairollah Asadollahi1Mir Hadi Musavi2Arezou Karimi3Gholam Ali Khademi4Monire Azizi5Ghobad Abangah6 Department of Epidemiology, School of Public Health, Ilam University of Medical Sciences, Ilam, Iran Department of Social Medicine, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran Department of Pediatrics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Department of Epidemiology, School of Public Health, Ilam University of Medical Sciences, Ilam, Iran Department of Non-Communicable diseases, Shiraz University of Medical Sciences, Shiraz, Iran Department of Anatomy, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran Department of Internal Medicine, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran Introduction: Glucose-6-phosphate dehydrogenase deficiency (G6PD) or fauvism is the most common enzyme deficiency in human, so that 400 million people are living with this disease worldwide. This study aimed to investigate the role of some neonatal factors among newborns suffering from G6PD deficiency and neonatal outcomes associated with this disease. Materials and methods: In this study, two methods including case-control and retrospective cohort regarding some neonatal factors associated with G6PD deficiency were used. These methods were performed on 142 children with this kind of deficiency and 142 healthy infants in the city of Marvdasht during 2013- 2014. The analysis of data was based on chi-square tests, t-test, logistic regression, descriptive statistics and estimation of odds ratios or relative risks via SPSS16 software. Results: Totally 284 newborns including 132 (46.6%)/ 152 (53.4%) boys/girls and mean weight on birth of 3163 ± 471 (gr) were analyzed. Comparison of case and control samples did not show any significant differences between sex and involving with G6PD deficiency but the chance of having a baby with this defect in pregnancy intervals between 6 to 8 years was increased (95% CI: 1- 4.4, OR: 2). Relative risk of jaundice in infected and healthy infants was estimated as 3.73, which demonstrated a statistically significant association (95% CI: 1.33- 10.4). The frequency of low birth weight, birth order and type of delivery was associated with the disease, but their differences were insignificant compared to the healthy group. Conclusion: The results of this study showed that the number of hospitalization is increased due to jaundice in infants with G6PD. There is also an insignificant relation between low birth weight, rank of birth and type of delivery. Thus, it is recommended that other consequences of this deficiency need to be revealed by screening other populations with more samples.http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-272-1&slc_lang=en&sid=1IranFarsFavismNeonateNewbornG6PD |
| spellingShingle | Salman Daliri Khairollah Asadollahi Mir Hadi Musavi Arezou Karimi Gholam Ali Khademi Monire Azizi Ghobad Abangah The relationship between neonatal factors and involving with glucose-6-phosphate dehydrogenase deficiency (G6PD) and patients\' outcome in Fars Province Journal of Basic Research in Medical Sciences Iran Fars Favism Neonate Newborn G6PD |
| title | The relationship between neonatal factors and involving with glucose-6-phosphate dehydrogenase deficiency (G6PD) and patients\' outcome in Fars Province |
| title_full | The relationship between neonatal factors and involving with glucose-6-phosphate dehydrogenase deficiency (G6PD) and patients\' outcome in Fars Province |
| title_fullStr | The relationship between neonatal factors and involving with glucose-6-phosphate dehydrogenase deficiency (G6PD) and patients\' outcome in Fars Province |
| title_full_unstemmed | The relationship between neonatal factors and involving with glucose-6-phosphate dehydrogenase deficiency (G6PD) and patients\' outcome in Fars Province |
| title_short | The relationship between neonatal factors and involving with glucose-6-phosphate dehydrogenase deficiency (G6PD) and patients\' outcome in Fars Province |
| title_sort | relationship between neonatal factors and involving with glucose 6 phosphate dehydrogenase deficiency g6pd and patients outcome in fars province |
| topic | Iran Fars Favism Neonate Newborn G6PD |
| url | http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-272-1&slc_lang=en&sid=1 |
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