Silica Nanoparticles in Transmucosal Drug Delivery
Transmucosal drug delivery includes the administration of drugs via various mucous membranes, such as gastrointestinal, nasal, ocular, and vaginal mucosa. The use of nanoparticles in transmucosal drug delivery has several advantages, including the protection of drugs against the harsh environment of...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/12/8/751 |
| _version_ | 1797559093254160384 |
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| author | Twana Mohammed M. Ways Keng Wooi Ng Wing Man Lau Vitaliy V. Khutoryanskiy |
| author_facet | Twana Mohammed M. Ways Keng Wooi Ng Wing Man Lau Vitaliy V. Khutoryanskiy |
| author_sort | Twana Mohammed M. Ways |
| collection | DOAJ |
| description | Transmucosal drug delivery includes the administration of drugs via various mucous membranes, such as gastrointestinal, nasal, ocular, and vaginal mucosa. The use of nanoparticles in transmucosal drug delivery has several advantages, including the protection of drugs against the harsh environment of the mucosal lumens and surfaces, increased drug residence time, and enhanced drug absorption. Due to their relatively simple synthetic methods for preparation, safety profile, and possibilities of surface functionalisation, silica nanoparticles are highly promising for transmucosal drug delivery. This review provides a description of silica nanoparticles and outlines the preparation methods for various core and surface-functionalised silica nanoparticles. The relationship between the functionalities of silica nanoparticles and their interactions with various mucous membranes are critically analysed. Applications of silica nanoparticles in transmucosal drug delivery are also discussed. |
| first_indexed | 2024-03-10T17:40:44Z |
| format | Article |
| id | doaj.art-5690d57a06ae46c4a6d7936ae29fead6 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T17:40:44Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-5690d57a06ae46c4a6d7936ae29fead62023-11-20T09:42:29ZengMDPI AGPharmaceutics1999-49232020-08-0112875110.3390/pharmaceutics12080751Silica Nanoparticles in Transmucosal Drug DeliveryTwana Mohammed M. Ways0Keng Wooi Ng1Wing Man Lau2Vitaliy V. Khutoryanskiy3Reading School of Pharmacy, University of Reading, Whiteknights, Reading RG6 6AD, UKSchool of Pharmacy, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE1 7RU, UKSchool of Pharmacy, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE1 7RU, UKReading School of Pharmacy, University of Reading, Whiteknights, Reading RG6 6AD, UKTransmucosal drug delivery includes the administration of drugs via various mucous membranes, such as gastrointestinal, nasal, ocular, and vaginal mucosa. The use of nanoparticles in transmucosal drug delivery has several advantages, including the protection of drugs against the harsh environment of the mucosal lumens and surfaces, increased drug residence time, and enhanced drug absorption. Due to their relatively simple synthetic methods for preparation, safety profile, and possibilities of surface functionalisation, silica nanoparticles are highly promising for transmucosal drug delivery. This review provides a description of silica nanoparticles and outlines the preparation methods for various core and surface-functionalised silica nanoparticles. The relationship between the functionalities of silica nanoparticles and their interactions with various mucous membranes are critically analysed. Applications of silica nanoparticles in transmucosal drug delivery are also discussed.https://www.mdpi.com/1999-4923/12/8/751silica nanoparticlesorganosilicatransmucosal drug deliverymucoadhesionmucosal penetration |
| spellingShingle | Twana Mohammed M. Ways Keng Wooi Ng Wing Man Lau Vitaliy V. Khutoryanskiy Silica Nanoparticles in Transmucosal Drug Delivery Pharmaceutics silica nanoparticles organosilica transmucosal drug delivery mucoadhesion mucosal penetration |
| title | Silica Nanoparticles in Transmucosal Drug Delivery |
| title_full | Silica Nanoparticles in Transmucosal Drug Delivery |
| title_fullStr | Silica Nanoparticles in Transmucosal Drug Delivery |
| title_full_unstemmed | Silica Nanoparticles in Transmucosal Drug Delivery |
| title_short | Silica Nanoparticles in Transmucosal Drug Delivery |
| title_sort | silica nanoparticles in transmucosal drug delivery |
| topic | silica nanoparticles organosilica transmucosal drug delivery mucoadhesion mucosal penetration |
| url | https://www.mdpi.com/1999-4923/12/8/751 |
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