Effects of COPD on Left Ventricular and Left Atrial Deformation in Patients with Acute Myocardial Infarction: Strain Analysis Using Speckle-Tracking Echocardiography
Myocardial strain analysis, which describes myocardial deformation (shortening or lengthening), provides more detailed information about left ventricular (LV) and atrial (LA) functions than conventional echocardiography and delivers prognostic information. To analyze the effects of COPD on left hear...
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| Format: | Article |
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MDPI AG
2022-03-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/7/1917 |
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| author | Julian Grebe Tobias Müller Ertunc Altiok Michael Becker András P. Keszei Nikolaus Marx Michael Dreher Ayham Daher |
| author_facet | Julian Grebe Tobias Müller Ertunc Altiok Michael Becker András P. Keszei Nikolaus Marx Michael Dreher Ayham Daher |
| author_sort | Julian Grebe |
| collection | DOAJ |
| description | Myocardial strain analysis, which describes myocardial deformation (shortening or lengthening), provides more detailed information about left ventricular (LV) and atrial (LA) functions than conventional echocardiography and delivers prognostic information. To analyze the effects of COPD on left heart function upon acute myocardial infarction (AMI), consecutive AMI patients were retrospectively screened, and patients were included if a post-AMI echocardiography and results of recent pulmonary function tests (PFTs) were available. Strain analysis was performed by a cardiologist who was blinded to clinical information. Overall, 109 AMI patients were included (STEMI: 38%, non-STEMI: 62%). COPD patients (41%) had significantly more impaired LV “global-longitudinal-strain” (LV-GLS) compared to non-COPD patients (−15 ± 4% vs. −18 ± 4%; <i>p</i> < 0.001, respectively), even after adjusting for LV-ejection-fraction (LVEF) and age (mean estimated difference: 1.7%, <i>p</i> = 0.009). Furthermore, COPD patients had more impaired LA strain (LAS) than non-COPD patients in all cardiac cycle phases (estimated mean differences after adjusting for LVEF and age: during reservoir phase: −7.5% (<i>p</i> < 0.001); conduit phase: 5.5% (<i>p</i> < 0.001); contraction phase: 1.9% (<i>p</i> = 0.034)). There were no correlations between PFT variables and strain values. In conclusion, the presence of COPD was associated with more impaired LV and LA functions after AMI, as detected by strain analysis, which was independent of age, LVEF, and PFT variables. |
| first_indexed | 2024-03-09T11:43:27Z |
| format | Article |
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| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T11:43:27Z |
| publishDate | 2022-03-01 |
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| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-56947dc33e464266a47c920c98672ede2023-11-30T23:28:38ZengMDPI AGJournal of Clinical Medicine2077-03832022-03-01117191710.3390/jcm11071917Effects of COPD on Left Ventricular and Left Atrial Deformation in Patients with Acute Myocardial Infarction: Strain Analysis Using Speckle-Tracking EchocardiographyJulian Grebe0Tobias Müller1Ertunc Altiok2Michael Becker3András P. Keszei4Nikolaus Marx5Michael Dreher6Ayham Daher7Department of Cardiology, Angiology and Intensive Care Medicine, University Hospital RWTH, 52074 Aachen, GermanyDepartment of Pneumology and Intensive Care Medicine, University Hospital RWTH, 52074 Aachen, GermanyDepartment of Cardiology, Angiology and Intensive Care Medicine, University Hospital RWTH, 52074 Aachen, GermanyDepartment of Cardiology, Angiology and Intensive Care Medicine, University Hospital RWTH, 52074 Aachen, GermanyCenter for Translational & Clinical Research Aachen (CTC-A), University Hospital RWTH, 52074 Aachen, GermanyDepartment of Cardiology, Angiology and Intensive Care Medicine, University Hospital RWTH, 52074 Aachen, GermanyDepartment of Pneumology and Intensive Care Medicine, University Hospital RWTH, 52074 Aachen, GermanyDepartment of Pneumology and Intensive Care Medicine, University Hospital RWTH, 52074 Aachen, GermanyMyocardial strain analysis, which describes myocardial deformation (shortening or lengthening), provides more detailed information about left ventricular (LV) and atrial (LA) functions than conventional echocardiography and delivers prognostic information. To analyze the effects of COPD on left heart function upon acute myocardial infarction (AMI), consecutive AMI patients were retrospectively screened, and patients were included if a post-AMI echocardiography and results of recent pulmonary function tests (PFTs) were available. Strain analysis was performed by a cardiologist who was blinded to clinical information. Overall, 109 AMI patients were included (STEMI: 38%, non-STEMI: 62%). COPD patients (41%) had significantly more impaired LV “global-longitudinal-strain” (LV-GLS) compared to non-COPD patients (−15 ± 4% vs. −18 ± 4%; <i>p</i> < 0.001, respectively), even after adjusting for LV-ejection-fraction (LVEF) and age (mean estimated difference: 1.7%, <i>p</i> = 0.009). Furthermore, COPD patients had more impaired LA strain (LAS) than non-COPD patients in all cardiac cycle phases (estimated mean differences after adjusting for LVEF and age: during reservoir phase: −7.5% (<i>p</i> < 0.001); conduit phase: 5.5% (<i>p</i> < 0.001); contraction phase: 1.9% (<i>p</i> = 0.034)). There were no correlations between PFT variables and strain values. In conclusion, the presence of COPD was associated with more impaired LV and LA functions after AMI, as detected by strain analysis, which was independent of age, LVEF, and PFT variables.https://www.mdpi.com/2077-0383/11/7/1917COPDechocardiographyleft atriumleft ventricleglobal longitudinal strainmyocardial dysfunction |
| spellingShingle | Julian Grebe Tobias Müller Ertunc Altiok Michael Becker András P. Keszei Nikolaus Marx Michael Dreher Ayham Daher Effects of COPD on Left Ventricular and Left Atrial Deformation in Patients with Acute Myocardial Infarction: Strain Analysis Using Speckle-Tracking Echocardiography Journal of Clinical Medicine COPD echocardiography left atrium left ventricle global longitudinal strain myocardial dysfunction |
| title | Effects of COPD on Left Ventricular and Left Atrial Deformation in Patients with Acute Myocardial Infarction: Strain Analysis Using Speckle-Tracking Echocardiography |
| title_full | Effects of COPD on Left Ventricular and Left Atrial Deformation in Patients with Acute Myocardial Infarction: Strain Analysis Using Speckle-Tracking Echocardiography |
| title_fullStr | Effects of COPD on Left Ventricular and Left Atrial Deformation in Patients with Acute Myocardial Infarction: Strain Analysis Using Speckle-Tracking Echocardiography |
| title_full_unstemmed | Effects of COPD on Left Ventricular and Left Atrial Deformation in Patients with Acute Myocardial Infarction: Strain Analysis Using Speckle-Tracking Echocardiography |
| title_short | Effects of COPD on Left Ventricular and Left Atrial Deformation in Patients with Acute Myocardial Infarction: Strain Analysis Using Speckle-Tracking Echocardiography |
| title_sort | effects of copd on left ventricular and left atrial deformation in patients with acute myocardial infarction strain analysis using speckle tracking echocardiography |
| topic | COPD echocardiography left atrium left ventricle global longitudinal strain myocardial dysfunction |
| url | https://www.mdpi.com/2077-0383/11/7/1917 |
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