Single-Dose Versus Multiple-Dose Ciprofloxacin Plus Metronidazole Prophylaxis in Transrectal Ultrasound-Guided Biopsy of the Prostate: a Randomized Controlled Trial
To investigate and compare the infectious and non-infectious complications of single-dose versus multiple-dose antibiotic therapy for trans-rectal ultrasound (TRUS)-guided biopsy of the prostate. Patients were enrolled in a prospective randomized study that was designed to investigate the effects of...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2014-09-01
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| Series: | Acta Medica Iranica |
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| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/4666 |
| _version_ | 1818827130781302784 |
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| author | Zhoobin Heidari Bateni Hossein Shahrokh Hormoz Salimi Hossein Safari Meghdad Tabatabai Dariush Saedi |
| author_facet | Zhoobin Heidari Bateni Hossein Shahrokh Hormoz Salimi Hossein Safari Meghdad Tabatabai Dariush Saedi |
| author_sort | Zhoobin Heidari Bateni |
| collection | DOAJ |
| description | To investigate and compare the infectious and non-infectious complications of single-dose versus multiple-dose antibiotic therapy for trans-rectal ultrasound (TRUS)-guided biopsy of the prostate. Patients were enrolled in a prospective randomized study that was designed to investigate the effects of single-dose versus multiple-dose antimicrobial prophylaxis regimen mainly on asymptomatic bacteriuria, urinary tract infection (UTI) without fever, fever and urinary septicemia. The single-dose group received one ciprofloxacin 500 mg tablet and two metronidazole 250 mg tablets at 2 hours before the biopsy, while the multiple-doses group received those every 12 hours from 3 days before the biopsy. One-hundred and sixty patients were evaluated in two groups and bacteriuria in urinalysis was encountered in 12 patients (15%) in the single-dose group and four patients (5%) in the multiple-dose group, with a significant difference (P=0.035). UTI without fever occurred in six patients (7.5%) in the single-dose group and one patient (1.25%) in the multiple-dose group, with no significant difference (borderline P=0.053). After biopsy, three patients (3.75%) returned with fever due to UTI and bacteremia in the single-dose group and none in the multiple-dose group, but with no significant difference (P=0.08). Regarding non-infectious complications, there were no significant differences between the two groups. Using prophylactic antibiotics for prostate biopsy in multiple doses, and at least 3 days before the procedure significantly reduces the rate of bacteriuria compared with a single-dose regimen. |
| first_indexed | 2024-12-19T00:38:40Z |
| format | Article |
| id | doaj.art-5694bc08b3534c54a875750e1ffb4307 |
| institution | Directory Open Access Journal |
| issn | 0044-6025 1735-9694 |
| language | English |
| last_indexed | 2024-12-19T00:38:40Z |
| publishDate | 2014-09-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-5694bc08b3534c54a875750e1ffb43072022-12-21T20:44:41ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942014-09-015294619Single-Dose Versus Multiple-Dose Ciprofloxacin Plus Metronidazole Prophylaxis in Transrectal Ultrasound-Guided Biopsy of the Prostate: a Randomized Controlled TrialZhoobin Heidari Bateni0Hossein Shahrokh1Hormoz Salimi2Hossein Safari3Meghdad Tabatabai4Dariush Saedi5Department of Urology, Hasheminejad Hospital, Iran University of Medical Sciences, Tehran, Iran.Department of Urology, Hasheminejad Hospital, Iran University of Medical Sciences, Tehran, Iran.Department of Urology, Hasheminejad Hospital, Iran University of Medical Sciences, Tehran, Iran.Department of Urology, Hasheminejad Hospital, Iran University of Medical Sciences, Tehran, Iran.Department of Urology, Hasheminejad Hospital, Iran University of Medical Sciences, Tehran, Iran.Department of Radiology, Hasheminejad Hospital, Iran University of Medical Sciences, Tehran, Iran.To investigate and compare the infectious and non-infectious complications of single-dose versus multiple-dose antibiotic therapy for trans-rectal ultrasound (TRUS)-guided biopsy of the prostate. Patients were enrolled in a prospective randomized study that was designed to investigate the effects of single-dose versus multiple-dose antimicrobial prophylaxis regimen mainly on asymptomatic bacteriuria, urinary tract infection (UTI) without fever, fever and urinary septicemia. The single-dose group received one ciprofloxacin 500 mg tablet and two metronidazole 250 mg tablets at 2 hours before the biopsy, while the multiple-doses group received those every 12 hours from 3 days before the biopsy. One-hundred and sixty patients were evaluated in two groups and bacteriuria in urinalysis was encountered in 12 patients (15%) in the single-dose group and four patients (5%) in the multiple-dose group, with a significant difference (P=0.035). UTI without fever occurred in six patients (7.5%) in the single-dose group and one patient (1.25%) in the multiple-dose group, with no significant difference (borderline P=0.053). After biopsy, three patients (3.75%) returned with fever due to UTI and bacteremia in the single-dose group and none in the multiple-dose group, but with no significant difference (P=0.08). Regarding non-infectious complications, there were no significant differences between the two groups. Using prophylactic antibiotics for prostate biopsy in multiple doses, and at least 3 days before the procedure significantly reduces the rate of bacteriuria compared with a single-dose regimen.https://acta.tums.ac.ir/index.php/acta/article/view/4666Transrectal UltrasonographicBiopsy of ProstateAntibiotic ProphylaxisProstate cancer |
| spellingShingle | Zhoobin Heidari Bateni Hossein Shahrokh Hormoz Salimi Hossein Safari Meghdad Tabatabai Dariush Saedi Single-Dose Versus Multiple-Dose Ciprofloxacin Plus Metronidazole Prophylaxis in Transrectal Ultrasound-Guided Biopsy of the Prostate: a Randomized Controlled Trial Acta Medica Iranica Transrectal Ultrasonographic Biopsy of Prostate Antibiotic Prophylaxis Prostate cancer |
| title | Single-Dose Versus Multiple-Dose Ciprofloxacin Plus Metronidazole Prophylaxis in Transrectal Ultrasound-Guided Biopsy of the Prostate: a Randomized Controlled Trial |
| title_full | Single-Dose Versus Multiple-Dose Ciprofloxacin Plus Metronidazole Prophylaxis in Transrectal Ultrasound-Guided Biopsy of the Prostate: a Randomized Controlled Trial |
| title_fullStr | Single-Dose Versus Multiple-Dose Ciprofloxacin Plus Metronidazole Prophylaxis in Transrectal Ultrasound-Guided Biopsy of the Prostate: a Randomized Controlled Trial |
| title_full_unstemmed | Single-Dose Versus Multiple-Dose Ciprofloxacin Plus Metronidazole Prophylaxis in Transrectal Ultrasound-Guided Biopsy of the Prostate: a Randomized Controlled Trial |
| title_short | Single-Dose Versus Multiple-Dose Ciprofloxacin Plus Metronidazole Prophylaxis in Transrectal Ultrasound-Guided Biopsy of the Prostate: a Randomized Controlled Trial |
| title_sort | single dose versus multiple dose ciprofloxacin plus metronidazole prophylaxis in transrectal ultrasound guided biopsy of the prostate a randomized controlled trial |
| topic | Transrectal Ultrasonographic Biopsy of Prostate Antibiotic Prophylaxis Prostate cancer |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/4666 |
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