MAP3K1 rs889312 polymorphism and cancer prognosis: A systematic review and meta‐analysis
Abstract Background Accumulating studies have evaluated the association between MAP3K1 polymorphisms and cancer prognosis. However, the results of these studies are conflicting. Given the potential impact of MAP3K1 rs889312 SNP on the prognosis of various cancers, this meta‐analysis was performed to...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Cancer Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cnr2.1773 |
| _version_ | 1811169290365173760 |
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| author | Md. Abdul Aziz Mohammad Safiqul Islam |
| author_facet | Md. Abdul Aziz Mohammad Safiqul Islam |
| author_sort | Md. Abdul Aziz |
| collection | DOAJ |
| description | Abstract Background Accumulating studies have evaluated the association between MAP3K1 polymorphisms and cancer prognosis. However, the results of these studies are conflicting. Given the potential impact of MAP3K1 rs889312 SNP on the prognosis of various cancers, this meta‐analysis was performed to obtain solid and credible evidence. Methods and Materials This study was performed according to the PRISMA 2020 statement. A comprehensive article search was conducted to find and select articles from multiple databases, including PubMed, Google Scholar, Web of Science, EMBASE and the Cochrane Library, published up to 15th September 2022. The data analysis was performed with Review Manager v5.2. Pooled HR with its 95% CI and p‐value was calculated where HR >1 suggests worse/poor survival and HR <1 suggests better survival of cancer patients. Results A total of five articles comprising 24 439 patients were included for both qualitative and quantitative data synthesis. It was found that only the dominant genetic model (AC + CC vs. AA) showed a statistically significant poor overall survival for MAP3K1 rs889312 polymorphism (HR = 1.25, 95% CI = 1.06–1.47, p = .01). In addition, publication bias analysis by the Egger's test and the Begg‐Mazumdar test reported no significant bias in the analysis of overall survival (p > .05). Conclusions The present study concludes that MAP3K1 gene rs889312 polymorphism plays a prognostic role in the survival of cancer patients. However, future research is recommended that will analyze more MAP3K SNPs along with rs889312, which may reveal more credible outcomes in terms of cancer prognosis. |
| first_indexed | 2024-04-10T16:39:54Z |
| format | Article |
| id | doaj.art-5696230a72e14297ac5a316e7362d383 |
| institution | Directory Open Access Journal |
| issn | 2573-8348 |
| language | English |
| last_indexed | 2024-04-10T16:39:54Z |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Reports |
| spelling | doaj.art-5696230a72e14297ac5a316e7362d3832023-02-08T07:31:30ZengWileyCancer Reports2573-83482023-01-0161n/an/a10.1002/cnr2.1773MAP3K1 rs889312 polymorphism and cancer prognosis: A systematic review and meta‐analysisMd. Abdul Aziz0Mohammad Safiqul Islam1Department of Pharmacy, Faculty of Pharmacy and Health Sciences State University of Bangladesh Dhaka BangladeshDepartment of Pharmacy, Faculty of Science Noakhali Science and Technology University Noakhali BangladeshAbstract Background Accumulating studies have evaluated the association between MAP3K1 polymorphisms and cancer prognosis. However, the results of these studies are conflicting. Given the potential impact of MAP3K1 rs889312 SNP on the prognosis of various cancers, this meta‐analysis was performed to obtain solid and credible evidence. Methods and Materials This study was performed according to the PRISMA 2020 statement. A comprehensive article search was conducted to find and select articles from multiple databases, including PubMed, Google Scholar, Web of Science, EMBASE and the Cochrane Library, published up to 15th September 2022. The data analysis was performed with Review Manager v5.2. Pooled HR with its 95% CI and p‐value was calculated where HR >1 suggests worse/poor survival and HR <1 suggests better survival of cancer patients. Results A total of five articles comprising 24 439 patients were included for both qualitative and quantitative data synthesis. It was found that only the dominant genetic model (AC + CC vs. AA) showed a statistically significant poor overall survival for MAP3K1 rs889312 polymorphism (HR = 1.25, 95% CI = 1.06–1.47, p = .01). In addition, publication bias analysis by the Egger's test and the Begg‐Mazumdar test reported no significant bias in the analysis of overall survival (p > .05). Conclusions The present study concludes that MAP3K1 gene rs889312 polymorphism plays a prognostic role in the survival of cancer patients. However, future research is recommended that will analyze more MAP3K SNPs along with rs889312, which may reveal more credible outcomes in terms of cancer prognosis.https://doi.org/10.1002/cnr2.1773cancerMAP3K1meta‐analysispolymorphismprognosissurvival |
| spellingShingle | Md. Abdul Aziz Mohammad Safiqul Islam MAP3K1 rs889312 polymorphism and cancer prognosis: A systematic review and meta‐analysis Cancer Reports cancer MAP3K1 meta‐analysis polymorphism prognosis survival |
| title | MAP3K1 rs889312 polymorphism and cancer prognosis: A systematic review and meta‐analysis |
| title_full | MAP3K1 rs889312 polymorphism and cancer prognosis: A systematic review and meta‐analysis |
| title_fullStr | MAP3K1 rs889312 polymorphism and cancer prognosis: A systematic review and meta‐analysis |
| title_full_unstemmed | MAP3K1 rs889312 polymorphism and cancer prognosis: A systematic review and meta‐analysis |
| title_short | MAP3K1 rs889312 polymorphism and cancer prognosis: A systematic review and meta‐analysis |
| title_sort | map3k1 rs889312 polymorphism and cancer prognosis a systematic review and meta analysis |
| topic | cancer MAP3K1 meta‐analysis polymorphism prognosis survival |
| url | https://doi.org/10.1002/cnr2.1773 |
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