Depletion of PD-1 or PD-L1 did not affect the mortality of mice infected with Mycobacterium avium

Depletion of PD-1 or PD-L1 did not affect the mortality of mice infected with Mycobacterium avium

Abstract The programmed cell death-1 (PD-1) and programmed cell death-ligand 1 (PD-L1) pathway could affect antimicrobial immune responses by suppressing T cell activity. Several recent studies demonstrated that blocking of the PD-1/PD-L1 pathway exacerbated Mycobacterium tuberculosis infection. How...

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Bibliographic Details
Main Authors: Masayuki Nakajima, Masashi Matsuyama, Mio Kawaguchi, Sosuke Matsumura, Takumi Kiwamoto, Yosuke Matsuno, Yuko Morishima, Kazufumi Yoshida, Mingma Thsering Sherpa, Kai Yazaki, Ryota Tanaka, Naoko Okiyama, Masafumi Muratani, Yukio Ishii, Nobuyuki Hizawa
Format: Article
Language:English
Published: Nature Portfolio 2021-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-97391-4

Internet

https://doi.org/10.1038/s41598-021-97391-4

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