First report of concomitant cryptococcal meningitis and anti-NMDAR encephalitis
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder, seen most often in young adults and children, triggered by tumors or infections. We report a case of cryptococcal meningitis in a patient with sarcoidosis, presenting prominent neuropsychiatric symptoms, electroenceph...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-02-01
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| Series: | Brain, Behavior, & Immunity - Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666354620300016 |
| _version_ | 1831559515739258880 |
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| author | Sofia R. Valdoleiros Margarida Calejo António Marinho Ana Martins da Silva Olga Vasconcelos Maria João Gonçalves Rui Sarmento e Castro |
| author_facet | Sofia R. Valdoleiros Margarida Calejo António Marinho Ana Martins da Silva Olga Vasconcelos Maria João Gonçalves Rui Sarmento e Castro |
| author_sort | Sofia R. Valdoleiros |
| collection | DOAJ |
| description | Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder, seen most often in young adults and children, triggered by tumors or infections. We report a case of cryptococcal meningitis in a patient with sarcoidosis, presenting prominent neuropsychiatric symptoms, electroencephalographic features of autoimmune encephalitis and positive anti-NMDAR antibodies in the cerebrospinal fluid, raising the hypothesis of an infectious immune-mediated mechanism triggering the production of anti-NMDAR antibodies. Since anti-NMDAR encephalitis is potentially fatal and has significant morbidity, further descriptions of its etiological associations are essential to early identification and prompt treatment. |
| first_indexed | 2024-12-17T05:30:06Z |
| format | Article |
| id | doaj.art-56973ecb750443e9a8455fafbc0f8721 |
| institution | Directory Open Access Journal |
| issn | 2666-3546 |
| language | English |
| last_indexed | 2024-12-17T05:30:06Z |
| publishDate | 2020-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain, Behavior, & Immunity - Health |
| spelling | doaj.art-56973ecb750443e9a8455fafbc0f87212022-12-21T22:01:45ZengElsevierBrain, Behavior, & Immunity - Health2666-35462020-02-012100036First report of concomitant cryptococcal meningitis and anti-NMDAR encephalitisSofia R. Valdoleiros0Margarida Calejo1António Marinho2Ana Martins da Silva3Olga Vasconcelos4Maria João Gonçalves5Rui Sarmento e Castro6Department of Infectious Diseases, Centro Hospitalar Universitário do Porto, Largo Prof. Abel Salazar, 4099-001, Porto, Portugal; Corresponding author.Department of Neurology, Centro Hospitalar Universitário do Porto, Largo Prof. Abel Salazar, 4099-001, Porto, PortugalDepartment of Internal Medicine, Centro Hospitalar Universitário do Porto, Largo Prof. Abel Salazar, 4099-001, Porto, Portugal; Unit for Multidisciplinary Research in Biomedicine, Instituto de Ciências Biomédicas Abel Salazar, University of Porto, 4099-001, Porto, PortugalDepartment of Neurology, Centro Hospitalar Universitário do Porto, Largo Prof. Abel Salazar, 4099-001, Porto, Portugal; Unit for Multidisciplinary Research in Biomedicine, Instituto de Ciências Biomédicas Abel Salazar, University of Porto, 4099-001, Porto, PortugalDepartment of Infectious Diseases, Centro Hospitalar Universitário do Porto, Largo Prof. Abel Salazar, 4099-001, Porto, PortugalDepartment of Infectious Diseases, Centro Hospitalar Universitário do Porto, Largo Prof. Abel Salazar, 4099-001, Porto, PortugalDepartment of Infectious Diseases, Centro Hospitalar Universitário do Porto, Largo Prof. Abel Salazar, 4099-001, Porto, PortugalAnti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder, seen most often in young adults and children, triggered by tumors or infections. We report a case of cryptococcal meningitis in a patient with sarcoidosis, presenting prominent neuropsychiatric symptoms, electroencephalographic features of autoimmune encephalitis and positive anti-NMDAR antibodies in the cerebrospinal fluid, raising the hypothesis of an infectious immune-mediated mechanism triggering the production of anti-NMDAR antibodies. Since anti-NMDAR encephalitis is potentially fatal and has significant morbidity, further descriptions of its etiological associations are essential to early identification and prompt treatment.http://www.sciencedirect.com/science/article/pii/S2666354620300016Anti-N-Methyl-D-Aspartate receptorAnti-N-Methyl-D-Aspartate receptor encephalitisCryptococcosisCryptococcal meningitisCryptococcus neoformansSarcoidosis |
| spellingShingle | Sofia R. Valdoleiros Margarida Calejo António Marinho Ana Martins da Silva Olga Vasconcelos Maria João Gonçalves Rui Sarmento e Castro First report of concomitant cryptococcal meningitis and anti-NMDAR encephalitis Brain, Behavior, & Immunity - Health Anti-N-Methyl-D-Aspartate receptor Anti-N-Methyl-D-Aspartate receptor encephalitis Cryptococcosis Cryptococcal meningitis Cryptococcus neoformans Sarcoidosis |
| title | First report of concomitant cryptococcal meningitis and anti-NMDAR encephalitis |
| title_full | First report of concomitant cryptococcal meningitis and anti-NMDAR encephalitis |
| title_fullStr | First report of concomitant cryptococcal meningitis and anti-NMDAR encephalitis |
| title_full_unstemmed | First report of concomitant cryptococcal meningitis and anti-NMDAR encephalitis |
| title_short | First report of concomitant cryptococcal meningitis and anti-NMDAR encephalitis |
| title_sort | first report of concomitant cryptococcal meningitis and anti nmdar encephalitis |
| topic | Anti-N-Methyl-D-Aspartate receptor Anti-N-Methyl-D-Aspartate receptor encephalitis Cryptococcosis Cryptococcal meningitis Cryptococcus neoformans Sarcoidosis |
| url | http://www.sciencedirect.com/science/article/pii/S2666354620300016 |
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