Synoviolin alleviates GSDMD‐mediated periodontitis by suppressing its stability

Synoviolin alleviates GSDMD‐mediated periodontitis by suppressing its stability

Abstract Introduction Inflammasome and pyroptosis play important roles in periodontitis. Gasdermin D (GSDMD), a key factor in pyroptosis, is cleaved by caspase‐1 and regulated by ubiquitination. Synoviolin is a ubiquitin E3 ligase that interacts with GSDMD. In this study, the effects of Synoviolin o...

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Bibliographic Details
Main Authors: Ying Pang, Lili Liu, Shuainan Wu, Jianqi Wang, Lu Liu
Format: Article
Language:English
Published: Wiley 2023-07-01
Series:Immunity, Inflammation and Disease
Subjects:
GSDMD
inflammasome
periodontitis
Synoviolin
Online Access:https://doi.org/10.1002/iid3.880

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