E-cadherin Expression in Canine Gastric Carcinomas: Association with Clinicopathological Parameters
E-cadherin (E-cad) is a cell-adhesion molecule known for its tumor-invasion suppressor function. E-cad expression was examined immunohistochemically in a series of canine tissue samples, including normal gastric mucosa (NGM; n = 3), gastric carcinomas (GC; n = 33), adjacent non-neoplastic mucosa (NN...
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MDPI AG
2022-04-01
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author | Ana R. Flores Alexandra Rêma João R. Mesquita Marian Taulescu Fernanda Seixas Fátima Gärtner Irina Amorim |
author_facet | Ana R. Flores Alexandra Rêma João R. Mesquita Marian Taulescu Fernanda Seixas Fátima Gärtner Irina Amorim |
author_sort | Ana R. Flores |
collection | DOAJ |
description | E-cadherin (E-cad) is a cell-adhesion molecule known for its tumor-invasion suppressor function. E-cad expression was examined immunohistochemically in a series of canine tissue samples, including normal gastric mucosa (NGM; n = 3), gastric carcinomas (GC; n = 33), adjacent non-neoplastic mucosa (NNM; n = 32), neoplastic emboli (n = 16) and metastatic lesions (n = 9). The relationship between E-cad expression and clinicopathological features were investigated. In NGM, epithelial cells showed strong latero-lateral membranous expression of E-cad, and this pattern was considered normal. The membranous staining was preserved in all specimens of NNM (100%), whereas abnormal E-cad expression was found in 87.9% of the GCs. A marked difference in E-cad expression was observed between normal and malignant tissues (<i>p</i> < 0.0002). Abnormal E-cad expression was significantly more frequent in poorly/undifferentiated carcinomas (96%) and diffuse (95%) and indeterminate carcinomas (100%) than in well-differentiated/intestinal ones (62.5%; <i>p</i> = 0.0115 and <i>p</i> = 0.0392, respectively). There was significant association between abnormal E-cad expression and the depth of invasion (<i>p</i> = 0.0117), and the presence neoplastic emboli (<i>p</i> = 0.0194). No statistically significant differences in E-cad expression were observed concerning tumor location, histological type according to WHO classification, and presence of metastatic lesions. Therefore, deregulation of E-cad expression may play a role in canine gastric carcinogenesis and in tumor progression; moreover, it might be a prognostic tool for canine gastric cancer. |
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spelling | doaj.art-5697b9ad58f247fc90c3b5f2362db39c2023-11-30T22:03:00ZengMDPI AGVeterinary Sciences2306-73812022-04-019417210.3390/vetsci9040172E-cadherin Expression in Canine Gastric Carcinomas: Association with Clinicopathological ParametersAna R. Flores0Alexandra Rêma1João R. Mesquita2Marian Taulescu3Fernanda Seixas4Fátima Gärtner5Irina Amorim6ICBAS—School of Medicine and Biomedical Sciences, University of Porto, 4050-313 Porto, PortugalICBAS—School of Medicine and Biomedical Sciences, University of Porto, 4050-313 Porto, PortugalICBAS—School of Medicine and Biomedical Sciences, University of Porto, 4050-313 Porto, PortugalDepartment of Pathology, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, RomaniaCECAV—Veterinary and Animal Research Center, University pf Trás-os-Montes and Alto Douro (UTAD), 5001-801 Vila Real, PortugalInstitute of Pathology and Molecular Immunology, University of Porto (IPATIMUP), 4200-465 Porto, PortugalICBAS—School of Medicine and Biomedical Sciences, University of Porto, 4050-313 Porto, PortugalE-cadherin (E-cad) is a cell-adhesion molecule known for its tumor-invasion suppressor function. E-cad expression was examined immunohistochemically in a series of canine tissue samples, including normal gastric mucosa (NGM; n = 3), gastric carcinomas (GC; n = 33), adjacent non-neoplastic mucosa (NNM; n = 32), neoplastic emboli (n = 16) and metastatic lesions (n = 9). The relationship between E-cad expression and clinicopathological features were investigated. In NGM, epithelial cells showed strong latero-lateral membranous expression of E-cad, and this pattern was considered normal. The membranous staining was preserved in all specimens of NNM (100%), whereas abnormal E-cad expression was found in 87.9% of the GCs. A marked difference in E-cad expression was observed between normal and malignant tissues (<i>p</i> < 0.0002). Abnormal E-cad expression was significantly more frequent in poorly/undifferentiated carcinomas (96%) and diffuse (95%) and indeterminate carcinomas (100%) than in well-differentiated/intestinal ones (62.5%; <i>p</i> = 0.0115 and <i>p</i> = 0.0392, respectively). There was significant association between abnormal E-cad expression and the depth of invasion (<i>p</i> = 0.0117), and the presence neoplastic emboli (<i>p</i> = 0.0194). No statistically significant differences in E-cad expression were observed concerning tumor location, histological type according to WHO classification, and presence of metastatic lesions. Therefore, deregulation of E-cad expression may play a role in canine gastric carcinogenesis and in tumor progression; moreover, it might be a prognostic tool for canine gastric cancer.https://www.mdpi.com/2306-7381/9/4/172doggastric carcinomastomachE-cadherin |
spellingShingle | Ana R. Flores Alexandra Rêma João R. Mesquita Marian Taulescu Fernanda Seixas Fátima Gärtner Irina Amorim E-cadherin Expression in Canine Gastric Carcinomas: Association with Clinicopathological Parameters Veterinary Sciences dog gastric carcinoma stomach E-cadherin |
title | E-cadherin Expression in Canine Gastric Carcinomas: Association with Clinicopathological Parameters |
title_full | E-cadherin Expression in Canine Gastric Carcinomas: Association with Clinicopathological Parameters |
title_fullStr | E-cadherin Expression in Canine Gastric Carcinomas: Association with Clinicopathological Parameters |
title_full_unstemmed | E-cadherin Expression in Canine Gastric Carcinomas: Association with Clinicopathological Parameters |
title_short | E-cadherin Expression in Canine Gastric Carcinomas: Association with Clinicopathological Parameters |
title_sort | e cadherin expression in canine gastric carcinomas association with clinicopathological parameters |
topic | dog gastric carcinoma stomach E-cadherin |
url | https://www.mdpi.com/2306-7381/9/4/172 |
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