Valproic Acid versus Lamotrigine as First-line Monotherapy in Newly Diagnosed Idiopathic Generalized Tonic –Clonic Seizures in Adults – A Randomized Controlled Trial
Introduction: Idiopathic Generalized Tonic-Clonic Seizures (GTCS) are frequently encountered in adults. Their successful control is necessary to improve the quality of life of these patients. Valproic acid is a simple branched-chain carboxylic acid and lamotrigine is a phenyltriazine derivative....
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2016-07-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/8121/16911_CE(Ra1)_F(GH)_PF1(ROAK)_PFA(AK)_PF2(PAG).pdf |
| Summary: | Introduction: Idiopathic Generalized Tonic-Clonic Seizures
(GTCS) are frequently encountered in adults. Their successful
control is necessary to improve the quality of life of these
patients. Valproic acid is a simple branched-chain carboxylic
acid and lamotrigine is a phenyltriazine derivative. Opinions
differ in regards to their effectiveness in idiopathic GTCS.
Aim: To compare the effectiveness of valproic acid and
lamotrigine in newly diagnosed adults with idiopathic generalized
tonic-clonic seizures.
Materials and Methods: The present prospective randomized
study was conducted on 60 patients suffering from idiopathic
GTCS. Thirty patients received valproic acid and rest 30
patients received lamotrigine. All patients were followed
regularly monthly for one year for treatment response and
adverse effects.
Results: After 12 months follow-up, 76.67% patients taking
valproic acid and 56.67% patients taking lamotrigine were
seizure-free. Common adverse effects recorded were nausea,
dyspepsia, headache and skin rash.
Conclusion: Valproic acid is more effective than lamotrigine as
first-line drug in the treatment of adults with newly diagnosed
idiopathic generalized tonic-clonic seizures. |
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| ISSN: | 2249-782X 0973-709X |