Comparison of LDL-Cholesterol Estimate using Various Formulae with Directly Measured LDL-Cholesterol in Indian Population
Introduction: Low-Density Lipoprotein Cholesterol (LDLc) is widely recognized as an established cardiovascular risk marker. Different formulae have been proposed for calculation of LDLc but have not been validated in Indian population and over a wide range of Triglycerides (TG). Friedewald formu...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2016-12-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/9018/22272_CE[Ra]_F(Sh)_PF1(PI_RK)_PFA(AK)_PF2(PAG).pdf |
| _version_ | 1817989631172411392 |
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| author | Nishtha Wadhwa Radhika Krishnaswamy |
| author_facet | Nishtha Wadhwa Radhika Krishnaswamy |
| author_sort | Nishtha Wadhwa |
| collection | DOAJ |
| description | Introduction: Low-Density Lipoprotein Cholesterol (LDLc) is
widely recognized as an established cardiovascular risk marker.
Different formulae have been proposed for calculation of LDLc
but have not been validated in Indian population and over a
wide range of Triglycerides (TG). Friedewald formula is most
commonly used which has various shortcomings.
Aim: To calculate LDLc using various formulae and compare
it with directly measured LDLc at various ranges of TG
concentration in Indian population.
Materials and Methods: One year lipid profile data of 21,503
samples was taken. Calculation of LDLc was done by the
following formulae: Friedewald; Cordova and Cordova; Vujovic;
Ahmadi; Anandaraja; Puavillai and Hattori. Comparison of
calculated LDLc with directly measured LDLc was done at
following TG ranges: <150mg/dL; 151-199mg/dL; 200-399mg/
dL and >400mg/dL using Pearson’s correlation coefficient and
two-paired t-test.
Results: For TG range <150mg/dL, Puavillai formula correlated
best with direct measurement (r = 0.978). For TG range
151-199mg/dL, Vujovic formula correlated best with direct
measurement (r = 0.977and mean difference of -1.2 mg/dL).
For TG range 200-399mg/dL, Vujovic formula correlated best
with direct measurement (r = 0.968). For TG range >400 mg/
dL, Vujovic formula correlated best with direct measurement (r
= 0.791).
Conclusion: Vujovic formula appears to be more accurate than
any other formula when applied to Indian population. |
| first_indexed | 2024-04-14T00:48:47Z |
| format | Article |
| id | doaj.art-569945c0f1ce40ec982499785c005a59 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-14T00:48:47Z |
| publishDate | 2016-12-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-569945c0f1ce40ec982499785c005a592022-12-22T02:21:53ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2016-12-011012BC11BC1310.7860/JCDR/2016/22272.9018Comparison of LDL-Cholesterol Estimate using Various Formulae with Directly Measured LDL-Cholesterol in Indian PopulationNishtha Wadhwa0Radhika Krishnaswamy1Postgraduate, Department of Biochemistry, St. John’s Medical College, Sarjapur Road, Bangalore, Karnataka, India.Associate Professor, Department of Biochemistry, St. John’s Medical College, Sarjapur Road, Bangalore, Karnataka, India.Introduction: Low-Density Lipoprotein Cholesterol (LDLc) is widely recognized as an established cardiovascular risk marker. Different formulae have been proposed for calculation of LDLc but have not been validated in Indian population and over a wide range of Triglycerides (TG). Friedewald formula is most commonly used which has various shortcomings. Aim: To calculate LDLc using various formulae and compare it with directly measured LDLc at various ranges of TG concentration in Indian population. Materials and Methods: One year lipid profile data of 21,503 samples was taken. Calculation of LDLc was done by the following formulae: Friedewald; Cordova and Cordova; Vujovic; Ahmadi; Anandaraja; Puavillai and Hattori. Comparison of calculated LDLc with directly measured LDLc was done at following TG ranges: <150mg/dL; 151-199mg/dL; 200-399mg/ dL and >400mg/dL using Pearson’s correlation coefficient and two-paired t-test. Results: For TG range <150mg/dL, Puavillai formula correlated best with direct measurement (r = 0.978). For TG range 151-199mg/dL, Vujovic formula correlated best with direct measurement (r = 0.977and mean difference of -1.2 mg/dL). For TG range 200-399mg/dL, Vujovic formula correlated best with direct measurement (r = 0.968). For TG range >400 mg/ dL, Vujovic formula correlated best with direct measurement (r = 0.791). Conclusion: Vujovic formula appears to be more accurate than any other formula when applied to Indian population.https://jcdr.net/articles/PDF/9018/22272_CE[Ra]_F(Sh)_PF1(PI_RK)_PFA(AK)_PF2(PAG).pdfcardiovascular diseasedirect low-density lipoprotein cholesterolvujovic formula |
| spellingShingle | Nishtha Wadhwa Radhika Krishnaswamy Comparison of LDL-Cholesterol Estimate using Various Formulae with Directly Measured LDL-Cholesterol in Indian Population Journal of Clinical and Diagnostic Research cardiovascular disease direct low-density lipoprotein cholesterol vujovic formula |
| title | Comparison of LDL-Cholesterol Estimate using Various Formulae with Directly Measured LDL-Cholesterol in Indian Population |
| title_full | Comparison of LDL-Cholesterol Estimate using Various Formulae with Directly Measured LDL-Cholesterol in Indian Population |
| title_fullStr | Comparison of LDL-Cholesterol Estimate using Various Formulae with Directly Measured LDL-Cholesterol in Indian Population |
| title_full_unstemmed | Comparison of LDL-Cholesterol Estimate using Various Formulae with Directly Measured LDL-Cholesterol in Indian Population |
| title_short | Comparison of LDL-Cholesterol Estimate using Various Formulae with Directly Measured LDL-Cholesterol in Indian Population |
| title_sort | comparison of ldl cholesterol estimate using various formulae with directly measured ldl cholesterol in indian population |
| topic | cardiovascular disease direct low-density lipoprotein cholesterol vujovic formula |
| url | https://jcdr.net/articles/PDF/9018/22272_CE[Ra]_F(Sh)_PF1(PI_RK)_PFA(AK)_PF2(PAG).pdf |
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