Multiple sclerosis plasma IgG aggregates induce complement-dependent neuronal apoptosis

Multiple sclerosis plasma IgG aggregates induce complement-dependent neuronal apoptosis

Abstract Grey matter pathology is central to the progression of multiple sclerosis (MS). We discovered that MS plasma immunoglobulin G (IgG) antibodies, mainly IgG1, form large aggregates (>100 nm) which are retained in the flow-through after binding to Protein A. Utilizing an annexin V live-cell...

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Bibliographic Details
Main Authors: Wenbo Zhou, Michael Graner, Petr Paucek, Cheryl Beseler, Matthew Boisen, Andrew Bubak, Francisco Asturias, Woro George, Arin Graner, David Ormond, Timothy Vollmer, Enrique Alvarez, Xiaoli Yu
Format: Article
Language:English
Published: Nature Publishing Group 2023-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-05783-3

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