Breast cancer mortality trends in Peruvian women
Abstract Background Breast cancer (BC) is the most common malignancy in Latin American women, but with a wide variability with respect to their mortality. This study aims to estimate the mortality rates from BC in Peruvian women and to assess mortality trends over 15 years. Methods We calculated BC...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-12-01
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| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12885-020-07671-x |
| _version_ | 1819176169687220224 |
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| author | J. Smith Torres-Roman Jose Fabian Martinez-Herrera Greta Carioli Jorge Ybaseta-Medina Bryan Valcarcel Joseph A. Pinto Alfredo Aguilar Katherine A. McGlynn Carlo La Vecchia |
| author_facet | J. Smith Torres-Roman Jose Fabian Martinez-Herrera Greta Carioli Jorge Ybaseta-Medina Bryan Valcarcel Joseph A. Pinto Alfredo Aguilar Katherine A. McGlynn Carlo La Vecchia |
| author_sort | J. Smith Torres-Roman |
| collection | DOAJ |
| description | Abstract Background Breast cancer (BC) is the most common malignancy in Latin American women, but with a wide variability with respect to their mortality. This study aims to estimate the mortality rates from BC in Peruvian women and to assess mortality trends over 15 years. Methods We calculated BC age-standardized mortality rate (ASMR) per 100,000 women-years using the world standard SEGI population. We estimated joinpoint regression models for BC in Peru and its geographical areas. The spatial analysis was performed using the Moran’s I statistic. Results In a 15-year period, Peru had a mortality rate of 9.97 per 100,000 women-years. The coastal region had the highest mortality rate (12.15 per 100,000 women-years), followed by the highlands region (4.71 per 100,000 women-years). In 2003, the highest ASMR for BC were in the provinces of Lima, Arequipa, and La Libertad (above 8.0 per 100,000 women-years), whereas in 2017, the highest ASMR were in Tumbes, Callao, and Moquegua (above 13.0 per women-years). The mortality trend for BC has been declining in the coastal region since 2005 (APC = − 1.35, p < 0.05), whereas the highlands region experienced an upward trend throughout the study period (APC = 4.26, p < 0.05). The rainforest region had a stable trend. Spatial analysis showed a Local Indicator of Spatial Association of 0.26 (p < 0.05). Conclusion We found regional differences in the mortality trends over 15 years. Although the coastal region experienced a downward trend, the highlands had an upward mortality trend in the entire study period. It is necessary to implement tailored public health interventions to reduce BC mortality in Peru. |
| first_indexed | 2024-12-22T21:06:30Z |
| format | Article |
| id | doaj.art-569a1d0801ab48719bdef4c4105792af |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-22T21:06:30Z |
| publishDate | 2020-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-569a1d0801ab48719bdef4c4105792af2022-12-21T18:12:40ZengBMCBMC Cancer1471-24072020-12-012011910.1186/s12885-020-07671-xBreast cancer mortality trends in Peruvian womenJ. Smith Torres-Roman0Jose Fabian Martinez-Herrera1Greta Carioli2Jorge Ybaseta-Medina3Bryan Valcarcel4Joseph A. Pinto5Alfredo Aguilar6Katherine A. McGlynn7Carlo La Vecchia8Universidad Cientifica del SurLatin American Network for Cancer Research (LAN–CANCER)Department of Clinical Sciences and Community Health, Università degli Studi di MilanoUniversidad Privada San Juan BautistaLatin American Network for Cancer Research (LAN–CANCER)Unidad de Investigación Básica y TraslacionalUnidad de Investigación Básica y TraslacionalDivision of Cancer Epidemiology and Genetics, National Cancer InstituteDepartment of Clinical Sciences and Community Health, Università degli Studi di MilanoAbstract Background Breast cancer (BC) is the most common malignancy in Latin American women, but with a wide variability with respect to their mortality. This study aims to estimate the mortality rates from BC in Peruvian women and to assess mortality trends over 15 years. Methods We calculated BC age-standardized mortality rate (ASMR) per 100,000 women-years using the world standard SEGI population. We estimated joinpoint regression models for BC in Peru and its geographical areas. The spatial analysis was performed using the Moran’s I statistic. Results In a 15-year period, Peru had a mortality rate of 9.97 per 100,000 women-years. The coastal region had the highest mortality rate (12.15 per 100,000 women-years), followed by the highlands region (4.71 per 100,000 women-years). In 2003, the highest ASMR for BC were in the provinces of Lima, Arequipa, and La Libertad (above 8.0 per 100,000 women-years), whereas in 2017, the highest ASMR were in Tumbes, Callao, and Moquegua (above 13.0 per women-years). The mortality trend for BC has been declining in the coastal region since 2005 (APC = − 1.35, p < 0.05), whereas the highlands region experienced an upward trend throughout the study period (APC = 4.26, p < 0.05). The rainforest region had a stable trend. Spatial analysis showed a Local Indicator of Spatial Association of 0.26 (p < 0.05). Conclusion We found regional differences in the mortality trends over 15 years. Although the coastal region experienced a downward trend, the highlands had an upward mortality trend in the entire study period. It is necessary to implement tailored public health interventions to reduce BC mortality in Peru.https://doi.org/10.1186/s12885-020-07671-xBreast cancerGeographic spatial analysisMortality rateEpidemiologyFemalePeru |
| spellingShingle | J. Smith Torres-Roman Jose Fabian Martinez-Herrera Greta Carioli Jorge Ybaseta-Medina Bryan Valcarcel Joseph A. Pinto Alfredo Aguilar Katherine A. McGlynn Carlo La Vecchia Breast cancer mortality trends in Peruvian women BMC Cancer Breast cancer Geographic spatial analysis Mortality rate Epidemiology Female Peru |
| title | Breast cancer mortality trends in Peruvian women |
| title_full | Breast cancer mortality trends in Peruvian women |
| title_fullStr | Breast cancer mortality trends in Peruvian women |
| title_full_unstemmed | Breast cancer mortality trends in Peruvian women |
| title_short | Breast cancer mortality trends in Peruvian women |
| title_sort | breast cancer mortality trends in peruvian women |
| topic | Breast cancer Geographic spatial analysis Mortality rate Epidemiology Female Peru |
| url | https://doi.org/10.1186/s12885-020-07671-x |
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