Functional analyses of heteromeric human PIEZO1 Channels.

Functional analyses of heteromeric human PIEZO1 Channels.

PIEZO1 and PIEZO2 are mechanosensitive channels (MSCs) important for cellular function and mutations in them lead to human disorders. We examined how functional heteromers form between subunits of PIEZO1 using the mutants E2117K, E2117D, and E2117A. Homomers of E2117K do not conduct. E2117A homomers...

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Bibliographic Details
Main Authors: Radhakrishnan Gnanasambandam, Chilman Bae, Lynn Ziegler, Frederick Sachs, Philip A Gottlieb
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6248943?pdf=render

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