Atopic Disease as a Risk Factor for Recurrent Herpetic Keratitis
Recurrent herpetic keratitis is a leading cause of blindness worldwide. In this population-based cross-sectional study, the medical records of Israeli adolescents and young adults who underwent systematic preconscription evaluation for mandatory military service were reviewed. The prevalence of atop...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/12/1/220 |
| _version_ | 1827369534119477248 |
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| author | Margarita Safir Michael Mimouni |
| author_facet | Margarita Safir Michael Mimouni |
| author_sort | Margarita Safir |
| collection | DOAJ |
| description | Recurrent herpetic keratitis is a leading cause of blindness worldwide. In this population-based cross-sectional study, the medical records of Israeli adolescents and young adults who underwent systematic preconscription evaluation for mandatory military service were reviewed. The prevalence of atopic conjunctival disease was evaluated in cases with and without documented recurrent herpetic keratitis. The association was tested using uni- and multivariant analyses. Overall, 940,892 adolescents and young adults were included. The mean age was 17.57 ± 1.50 years (range 16–20 years), and 40.70% of participants were female. Recurrent herpetic keratitis was documented in 160 cases, with a prevalence of 0.017% in this age group. Compared to the general population, patients with recurrent herpetic keratitis were significantly more likely to be males (<i>p</i> = 0.003) with a concomitant diagnosis of atopic conjunctival disease (<i>p</i> < 0.0001). Patients with atopic conjunctival disease were 10.60-fold more likely to experience recurrent herpetic keratitis (95% confidence interval (CI): 6.76–16.64, <i>p</i> < 0.0001). Upon multivariate analysis, the results remained significant (<i>p</i> < 0.001). Cases of severe atopic conjunctival disease were more prone to recurrent HSV keratitis compared to mild cases (<i>p</i> < 0.001). These findings suggest that the timely appropriate treatment of atopic conjunctival disease may help reduce the frequency and severity of recurrent HSV keratitis and its complications. |
| first_indexed | 2024-03-08T09:49:36Z |
| format | Article |
| id | doaj.art-569c4630801549b68104959020ce0984 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-08T09:49:36Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-569c4630801549b68104959020ce09842024-01-29T14:07:08ZengMDPI AGMicroorganisms2076-26072024-01-0112122010.3390/microorganisms12010220Atopic Disease as a Risk Factor for Recurrent Herpetic KeratitisMargarita Safir0Michael Mimouni1Ophthalmology Department, Yitzhak Shamir Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, IsraelOphthalmology Department, Rambam Health Care Campus, Haifa 3109601, IsraelRecurrent herpetic keratitis is a leading cause of blindness worldwide. In this population-based cross-sectional study, the medical records of Israeli adolescents and young adults who underwent systematic preconscription evaluation for mandatory military service were reviewed. The prevalence of atopic conjunctival disease was evaluated in cases with and without documented recurrent herpetic keratitis. The association was tested using uni- and multivariant analyses. Overall, 940,892 adolescents and young adults were included. The mean age was 17.57 ± 1.50 years (range 16–20 years), and 40.70% of participants were female. Recurrent herpetic keratitis was documented in 160 cases, with a prevalence of 0.017% in this age group. Compared to the general population, patients with recurrent herpetic keratitis were significantly more likely to be males (<i>p</i> = 0.003) with a concomitant diagnosis of atopic conjunctival disease (<i>p</i> < 0.0001). Patients with atopic conjunctival disease were 10.60-fold more likely to experience recurrent herpetic keratitis (95% confidence interval (CI): 6.76–16.64, <i>p</i> < 0.0001). Upon multivariate analysis, the results remained significant (<i>p</i> < 0.001). Cases of severe atopic conjunctival disease were more prone to recurrent HSV keratitis compared to mild cases (<i>p</i> < 0.001). These findings suggest that the timely appropriate treatment of atopic conjunctival disease may help reduce the frequency and severity of recurrent HSV keratitis and its complications.https://www.mdpi.com/2076-2607/12/1/220herpes simplex viruskeratitisatopic conjunctivitis |
| spellingShingle | Margarita Safir Michael Mimouni Atopic Disease as a Risk Factor for Recurrent Herpetic Keratitis Microorganisms herpes simplex virus keratitis atopic conjunctivitis |
| title | Atopic Disease as a Risk Factor for Recurrent Herpetic Keratitis |
| title_full | Atopic Disease as a Risk Factor for Recurrent Herpetic Keratitis |
| title_fullStr | Atopic Disease as a Risk Factor for Recurrent Herpetic Keratitis |
| title_full_unstemmed | Atopic Disease as a Risk Factor for Recurrent Herpetic Keratitis |
| title_short | Atopic Disease as a Risk Factor for Recurrent Herpetic Keratitis |
| title_sort | atopic disease as a risk factor for recurrent herpetic keratitis |
| topic | herpes simplex virus keratitis atopic conjunctivitis |
| url | https://www.mdpi.com/2076-2607/12/1/220 |
| work_keys_str_mv | AT margaritasafir atopicdiseaseasariskfactorforrecurrentherpetickeratitis AT michaelmimouni atopicdiseaseasariskfactorforrecurrentherpetickeratitis |